Safety, tolerability, and immunogenicity of a DNA-based vaccine (INO-4700) against Middle East respiratory syndrome coronavirus: phase 2a study in healthy volunteers.
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| Title: | Safety, tolerability, and immunogenicity of a DNA-based vaccine (INO-4700) against Middle East respiratory syndrome coronavirus: phase 2a study in healthy volunteers. |
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| Authors: | Agnes JT; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Marcus SA; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Al-Ghraibeh SS; Department of Internal Medicine, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Al-Sweedan SA; Department of Pediatric Hematology/Oncology/BMT, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science & Technology, Ar Ramtha, Irbid, Jordan., Kosgei J; Kenya Medical Research Institute/Walter Reed Project Clinical Research Center, Kericho Clinical Research Site, Kericho, Kenya., Ogutu B; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya., Yang S; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Walker KA; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Orizu B; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Broderick KE; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Boyer J; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Ramos S; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Morrow MP; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Kraynyak K; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Sylvester AJ; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Gillespie E; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Liebowitz D; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States., Humeau LM; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Nov 14; Vol. 16, pp. 1662923. Date of Electronic Publication: 2025 Nov 14 (Print Publication: 2025). |
| Publication Type: | Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41322416 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety, tolerability, and immunogenicity of a DNA-based vaccine (INO-4700) against Middle East respiratory syndrome coronavirus: phase 2a study in healthy volunteers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Agnes+JT%22">Agnes JT</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Marcus+SA%22">Marcus SA</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Al-Ghraibeh+SS%22">Al-Ghraibeh SS</searchLink>; Department of Internal Medicine, Faculty of Medicine, Yarmouk University, Irbid, Jordan.<br /><searchLink fieldCode="AU" term="%22Al-Sweedan+SA%22">Al-Sweedan SA</searchLink>; Department of Pediatric Hematology/Oncology/BMT, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science & Technology, Ar Ramtha, Irbid, Jordan.<br /><searchLink fieldCode="AU" term="%22Kosgei+J%22">Kosgei J</searchLink>; Kenya Medical Research Institute/Walter Reed Project Clinical Research Center, Kericho Clinical Research Site, Kericho, Kenya.<br /><searchLink fieldCode="AU" term="%22Ogutu+B%22">Ogutu B</searchLink>; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Walker+KA%22">Walker KA</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Orizu+B%22">Orizu B</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Broderick+KE%22">Broderick KE</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Boyer+J%22">Boyer J</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Ramos+S%22">Ramos S</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Morrow+MP%22">Morrow MP</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Kraynyak+K%22">Kraynyak K</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Sylvester+AJ%22">Sylvester AJ</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Gillespie+E%22">Gillespie E</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Liebowitz+D%22">Liebowitz D</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States.<br /><searchLink fieldCode="AU" term="%22Humeau+LM%22">Humeau LM</searchLink>; Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 Nov 14; Vol. 16, pp. 1662923. <i>Date of Electronic Publication: </i>2025 Nov 14 (<i>Print Publication: </i>2025). – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41322416 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fimmu.2025.1662923 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1662923 Titles: – TitleFull: Safety, tolerability, and immunogenicity of a DNA-based vaccine (INO-4700) against Middle East respiratory syndrome coronavirus: phase 2a study in healthy volunteers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Agnes JT – PersonEntity: Name: NameFull: Marcus SA – PersonEntity: Name: NameFull: Al-Ghraibeh SS – PersonEntity: Name: NameFull: Al-Sweedan SA – PersonEntity: Name: NameFull: Kosgei J – PersonEntity: Name: NameFull: Ogutu B – PersonEntity: Name: NameFull: Yang S – PersonEntity: Name: NameFull: Walker KA – PersonEntity: Name: NameFull: Orizu B – PersonEntity: Name: NameFull: Broderick KE – PersonEntity: Name: NameFull: Boyer J – PersonEntity: Name: NameFull: Ramos S – PersonEntity: Name: NameFull: Morrow MP – PersonEntity: Name: NameFull: Kraynyak K – PersonEntity: Name: NameFull: Sylvester AJ – PersonEntity: Name: NameFull: Gillespie E – PersonEntity: Name: NameFull: Liebowitz D – PersonEntity: Name: NameFull: Humeau LM IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 11 Text: 2025 Nov 14 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1664-3224 Numbering: – Type: volume Value: 16 Titles: – TitleFull: Frontiers in immunology Type: main |
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