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Reduced FEV3/FVC as an Early Indicator of COPD in Individuals with Normal Spirometry: A Prospective Analysis from the ECOPD Study.

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Title: Reduced FEV3/FVC as an Early Indicator of COPD in Individuals with Normal Spirometry: A Prospective Analysis from the ECOPD Study.
Authors: Li Y; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Li J; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Huang S; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China., Wu F; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Deng Z; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Peng J; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China., Zhou K; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Tang G; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Wan Q; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Dai C; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Lu L; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Wu X; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China., Zeng X; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Wu F; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China., Yang C; Department of Pulmonary Medicine, Wengyuan County People's Hospital, Shaoguan, People's Republic of China., Chen S; Department of Radiology, Wengyuan County People's Hospital, Shaoguan, People's Republic of China., Huang Y; Intensive Care Unit, Lianping County People's Hospital, Heyuan, People's Republic of China., Yu S; Department of Pulmonary Medicine, Lianping County People's Hospital & Lianping County Second People's Hospital, Heyuan, People's Republic of China., Zhou Y; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China., Ran P; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China.
Source: International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2025 Nov 25; Vol. 20, pp. 3791-3802. Date of Electronic Publication: 2025 Nov 25 (Print Publication: 2025).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101273481 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2005 (Electronic) Linking ISSN: 11769106 NLM ISO Abbreviation: Int J Chron Obstruct Pulmon Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reduced FEV<subscript>3</subscript>/FVC as an Early Indicator of COPD in Individuals with Normal Spirometry: A Prospective Analysis from the ECOPD Study.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Deng+Z%22">Deng Z</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Peng+J%22">Peng J</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhou+K%22">Zhou K</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Tang+G%22">Tang G</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wan+Q%22">Wan Q</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Dai+C%22">Dai C</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Department of Pulmonary Medicine, Wengyuan County People's Hospital, Shaoguan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Radiology, Wengyuan County People's Hospital, Shaoguan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Intensive Care Unit, Lianping County People's Hospital, Heyuan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yu+S%22">Yu S</searchLink>; Department of Pulmonary Medicine, Lianping County People's Hospital & Lianping County Second People's Hospital, Heyuan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ran+P%22">Ran P</searchLink>; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine & Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangzhou National Laboratory, Guangzhou, People's Republic of China.
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  Data: <searchLink fieldCode="JN" term="%22101273481%22">International journal of chronic obstructive pulmonary disease</searchLink> [Int J Chron Obstruct Pulmon Dis] 2025 Nov 25; Vol. 20, pp. 3791-3802. <i>Date of Electronic Publication: </i>2025 Nov 25 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22DOVE+Medical+Press%22">DOVE Medical Press </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>101273481 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1178-2005 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211769106%22">11769106 </searchLink><i>NLM ISO Abbreviation: </i>Int J Chron Obstruct Pulmon Dis <i>Subsets: </i>MEDLINE
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        Value: 10.2147/COPD.S566651
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              Text: 2025 Nov 25
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