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Temporal robustness of biomarker-based classification algorithms for sepsis.

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Title: Temporal robustness of biomarker-based classification algorithms for sepsis.
Authors: Rademaker E; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. e.rademaker-2@umcutrecht.nl.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands. e.rademaker-2@umcutrecht.nl., van Amstel RBE; Department of Intensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., El Bouhaddani S; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands., Bonten MJM; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; European Clinical Research Alliance on Infectious Diseases, Utrecht, The Netherlands., Derde LPG; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands., van Vught L; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands., van der Poll T; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Bos LDJ; Department of Intensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., de Grooth HJ; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands., Cremer OL; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Source: Intensive care medicine [Intensive Care Med] 2026 Jan; Vol. 52 (1), pp. 22-30. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Rademaker+E%22">Rademaker E</searchLink>; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. e.rademaker-2@umcutrecht.nl.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands. e.rademaker-2@umcutrecht.nl.<br /><searchLink fieldCode="AU" term="%22van+Amstel+RBE%22">van Amstel RBE</searchLink>; Department of Intensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22El+Bouhaddani+S%22">El Bouhaddani S</searchLink>; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bonten+MJM%22">Bonten MJM</searchLink>; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; European Clinical Research Alliance on Infectious Diseases, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Derde+LPG%22">Derde LPG</searchLink>; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Vught+L%22">van Vught L</searchLink>; Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Poll+T%22">van der Poll T</searchLink>; Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bos+LDJ%22">Bos LDJ</searchLink>; Department of Intensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Grooth+HJ%22">de Grooth HJ</searchLink>; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cremer+OL%22">Cremer OL</searchLink>; Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%227704851%22">Intensive care medicine</searchLink> [Intensive Care Med] 2026 Jan; Vol. 52 (1), pp. 22-30. <i>Date of Electronic Publication: </i>2025 Dec 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7704851 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203424642%22">03424642 </searchLink><i>NLM ISO Abbreviation: </i>Intensive Care Med <i>Subsets: </i>MEDLINE
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              Text: 2026 Jan
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