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Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clinical Benefit and Neurodegeneration in Early Symptomatic Alzheimer's Disease: Synthesis of Evidence from Observational and Interventional Trials.

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Title: Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clinical Benefit and Neurodegeneration in Early Symptomatic Alzheimer's Disease: Synthesis of Evidence from Observational and Interventional Trials.
Authors: Abushakra S; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA. susan.abushakra@alzheon.com., Doraiswamy PM; Departments of Psychiatry and Medicine, Duke University School of Medicine, Durham, NC, USA., Hey JA; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Tosun D; Departments of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Barkhof F; Department of Neuroradiology, VU University Medical Center, Amsterdam, The Netherlands.; Queen Square Institute of Neurology and Center of Medical Imaging Computing, University College, London, UK., Barakos J; California Pacific Advanced Imaging and Sutter Health, San Francisco, CA, USA., Petrella J; Department of Radiology, Duke University School of Medicine, Durham, NC, USA., Kesslak JP; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Power A; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Sabbagh M; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA., Porsteinsson A; Departments of Psychiatry, Neurology, Neuroscience, and Medicine/Geriatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Cohen S; Toronto Memory Program, Toronto, Canada., Gauthier S; Departments of Neurology and Neurosurgery, Psychiatry, and Medicine, McGill University, Montreal, Canada., Ritchie C; University of St. Andrews Medical School and Scottish Brain Sciences, Edinburgh, Scotland, UK., Watson D; Alzheimer's Research and Treatment Center, Wellington, FL, USA., McSweeney E; Re:Cognition Health, London, UK., Boada M; Ace Alzheimer Center, Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases, Instituto de Salud Carlos III, Madrid, Spain., Liang E; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Bracoud L; Clario Inc, Lyon, France., McLaine R; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Flint S; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Schaefer JF; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Yu J; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Bray M; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Hendrix S; Pentara Corporation, Salt Lake City, UT, USA., Dickson S; Pentara Corporation, Salt Lake City, UT, USA., Durrant A; Pentara Corporation, Salt Lake City, UT, USA., Albayrak A; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA., Tolar M; Alzheon, Inc., 111 Speen Street, Suite 306, Framingham, MA, 01701, USA.
Source: CNS drugs [CNS Drugs] 2026 Feb; Vol. 40 (2), pp. 199-214. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
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