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Probing Guanidino Pendant or Bridged Groups in Cyclic Antimicrobial Peptides Derived from Temporin L: A Strategy to Improve Efficacy against Gram-Negative Bacteria.

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Title: Probing Guanidino Pendant or Bridged Groups in Cyclic Antimicrobial Peptides Derived from Temporin L: A Strategy to Improve Efficacy against Gram-Negative Bacteria.
Authors: Bellavita R; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy., Boccino I; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy., Loffredo MR; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy., Palladino S; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy., Cappiello F; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy., Vetrano C; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy., Tortellini E; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy., Mazzarella V; DiSTABiF, University of Campania Luigi Vanvitelli, via Vivaldi 43, 81100 Caserta, Italy., Di Maro S; DiSTABiF, University of Campania Luigi Vanvitelli, via Vivaldi 43, 81100 Caserta, Italy., Galdiero S; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy., Casciaro B; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy., Grieco P; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy., Mangoni ML; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy., Merlino F; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Dec 11; Vol. 68 (23), pp. 25038-25060. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Probing Guanidino Pendant or Bridged Groups in Cyclic Antimicrobial Peptides Derived from Temporin L: A Strategy to Improve Efficacy against Gram-Negative Bacteria.
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  Data: <searchLink fieldCode="AU" term="%22Bellavita+R%22">Bellavita R</searchLink>; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Boccino+I%22">Boccino I</searchLink>; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Loffredo+MR%22">Loffredo MR</searchLink>; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Palladino+S%22">Palladino S</searchLink>; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cappiello+F%22">Cappiello F</searchLink>; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Vetrano+C%22">Vetrano C</searchLink>; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Tortellini+E%22">Tortellini E</searchLink>; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzarella+V%22">Mazzarella V</searchLink>; DiSTABiF, University of Campania Luigi Vanvitelli, via Vivaldi 43, 81100 Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Maro+S%22">Di Maro S</searchLink>; DiSTABiF, University of Campania Luigi Vanvitelli, via Vivaldi 43, 81100 Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Galdiero+S%22">Galdiero S</searchLink>; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Casciaro+B%22">Casciaro B</searchLink>; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Grieco+P%22">Grieco P</searchLink>; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Mangoni+ML%22">Mangoni ML</searchLink>; Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, p.le Aldo Moro 5, Rome 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Merlino+F%22">Merlino F</searchLink>; Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Dec 11; Vol. 68 (23), pp. 25038-25060. <i>Date of Electronic Publication: </i>2025 Dec 01.
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