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Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation.

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Title: Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation.
Authors: Gaebler C; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. christian.gaebler@charite.de.; Berlin Institute of Health, Berlin, Germany. christian.gaebler@charite.de., Kor S; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany., Allers K; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Perotti M; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Mwangi D; Laboratory MVZ MIB-Medical Center for Infectious Diseases, Berlin, Germany., Meixenberger K; Division of Sexually Transmitted Bacterial Pathogens (STI) and HIV, Robert Koch Institute, Berlin, Germany., Hanke K; Division of Sexually Transmitted Bacterial Pathogens (STI) and HIV, Robert Koch Institute, Berlin, Germany., Trenkner T; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kraus T; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sha Y; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Arentowicz C; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Odidika S; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Grahn N; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Scheck R; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Perkins N; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Pardons M; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Igbokwe V; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Corman V; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Labor Berlin-Charité Vivantes, Berlin, Germany., Burmeister T; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany., Blau O; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany., Sürücü G; Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Pruß A; Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Schneider CG; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany., Klausen G; SPP-Mitte, Specialist Practice for Infection Medicine at Oranienburger Tor, Berlin, Germany., Sauter J; DKMS Group, Tübingen, Germany., Klein F; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Sander LE; Berlin Institute of Health, Berlin, Germany.; Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Hofmann J; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Labor Berlin-Charité Vivantes, Berlin, Germany., Vuong L; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany., Bullinger L; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany., Penter L; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Gruell H; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Reeves DB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Schommers P; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Hoelzemer A; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Leibniz Institute of Virology, Hamburg, Germany.; Institute for Infection and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Obermeier M; Laboratory MVZ MIB-Medical Center for Infectious Diseases, Berlin, Germany., Blau IW; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany., Schneider T; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Penack O; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. olaf.penack@charite.de.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany. olaf.penack@charite.de.
Source: Nature [Nature] 2026 Feb; Vol. 650 (8102), pp. 701-709. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article; Case Reports; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation.
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  Data: <searchLink fieldCode="AU" term="%22Gaebler+C%22">Gaebler C</searchLink>; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. christian.gaebler@charite.de.; Berlin Institute of Health, Berlin, Germany. christian.gaebler@charite.de.<br /><searchLink fieldCode="AU" term="%22Kor+S%22">Kor S</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Allers+K%22">Allers K</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Perotti+M%22">Perotti M</searchLink>; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mwangi+D%22">Mwangi D</searchLink>; Laboratory MVZ MIB-Medical Center for Infectious Diseases, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Meixenberger+K%22">Meixenberger K</searchLink>; Division of Sexually Transmitted Bacterial Pathogens (STI) and HIV, Robert Koch Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hanke+K%22">Hanke K</searchLink>; Division of Sexually Transmitted Bacterial Pathogens (STI) and HIV, Robert Koch Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Trenkner+T%22">Trenkner T</searchLink>; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kraus+T%22">Kraus T</searchLink>; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sha+Y%22">Sha Y</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Arentowicz+C%22">Arentowicz C</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Odidika+S%22">Odidika S</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Grahn+N%22">Grahn N</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Scheck+R%22">Scheck R</searchLink>; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Perkins+N%22">Perkins N</searchLink>; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pardons+M%22">Pardons M</searchLink>; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Igbokwe+V%22">Igbokwe V</searchLink>; Laboratory of Translational Immunology of Viral Infections, Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Corman+V%22">Corman V</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Labor Berlin-Charité Vivantes, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Burmeister+T%22">Burmeister T</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Blau+O%22">Blau O</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sürücü+G%22">Sürücü G</searchLink>; Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pruß+A%22">Pruß A</searchLink>; Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+CG%22">Schneider CG</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Klausen+G%22">Klausen G</searchLink>; SPP-Mitte, Specialist Practice for Infection Medicine at Oranienburger Tor, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sauter+J%22">Sauter J</searchLink>; DKMS Group, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Klein+F%22">Klein F</searchLink>; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sander+LE%22">Sander LE</searchLink>; Berlin Institute of Health, Berlin, Germany.; Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+J%22">Hofmann J</searchLink>; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Labor Berlin-Charité Vivantes, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Vuong+L%22">Vuong L</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bullinger+L%22">Bullinger L</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Penter+L%22">Penter L</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gruell+H%22">Gruell H</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Reeves+DB%22">Reeves DB</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Schommers+P%22">Schommers P</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hoelzemer+A%22">Hoelzemer A</searchLink>; First Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Leibniz Institute of Virology, Hamburg, Germany.; Institute for Infection and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Obermeier+M%22">Obermeier M</searchLink>; Laboratory MVZ MIB-Medical Center for Infectious Diseases, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Blau+IW%22">Blau IW</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+T%22">Schneider T</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Penack+O%22">Penack O</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. olaf.penack@charite.de.; National Center for Tumor Diseases (NCT), Partner Site, Berlin, Germany. olaf.penack@charite.de.
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              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 650
            – Type: issue
              Value: 8102
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1