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Longitudinal multiomic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality.

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Title: Longitudinal multiomic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality.
Authors: Alipanah-Lechner N; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Neyton L; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Sinha P; Division of Clinical and Translational Research, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA., Leroux C; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Bardillon K; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Carrillo SA; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Chak S; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Chao O; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Hariharan T; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Hendrickson C; Division of Pulmonary and Critical Care, Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, California, USA., Kangelaris K; Division of Hospital Medicine, Department of Medicine., Langelier CR; Division of Infectious Disease, Department of Medicine., Lee D; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Lin C; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Liu K; Division of Nephrology, Department of Medicine; and.; Department of Anesthesia, UCSF, San Francisco, California, USA., Magee L; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Ringor A; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Sarma A; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Schmiege E; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Spottiswoode N; Division of Infectious Disease, Department of Medicine., Sullivan K; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Weingart MF; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Willmore A; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA., Zhuo H; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Rogers AJ; Division of Pulmonary and Critical Care, Department of Medicine, Stanford University, Stanford, California, USA., Stringer KA; Department of Clinical Pharmacy, College of Pharmacy, and.; Division of Pulmonary and Critical Care Medicine and.; Weil Institute for Critical Care Research & Innovation, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA., Matthay MA; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.; Department of Anesthesia, UCSF, San Francisco, California, USA., Calfee CS; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.; Department of Anesthesia, UCSF, San Francisco, California, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Dec 02; Vol. 136 (3). Date of Electronic Publication: 2025 Dec 02 (Print Publication: 2026).
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Longitudinal multiomic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality.
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  Data: <searchLink fieldCode="AU" term="%22Alipanah-Lechner+N%22">Alipanah-Lechner N</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Neyton+L%22">Neyton L</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Sinha+P%22">Sinha P</searchLink>; Division of Clinical and Translational Research, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Leroux+C%22">Leroux C</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Bardillon+K%22">Bardillon K</searchLink>; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Carrillo+SA%22">Carrillo SA</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Chak+S%22">Chak S</searchLink>; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Chao+O%22">Chao O</searchLink>; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Hariharan+T%22">Hariharan T</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Hendrickson+C%22">Hendrickson C</searchLink>; Division of Pulmonary and Critical Care, Department of Medicine, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Kangelaris+K%22">Kangelaris K</searchLink>; Division of Hospital Medicine, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Langelier+CR%22">Langelier CR</searchLink>; Division of Infectious Disease, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Lin+C%22">Lin C</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Division of Nephrology, Department of Medicine; and.; Department of Anesthesia, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Magee+L%22">Magee L</searchLink>; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Ringor+A%22">Ringor A</searchLink>; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Sarma+A%22">Sarma A</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Schmiege+E%22">Schmiege E</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Spottiswoode+N%22">Spottiswoode N</searchLink>; Division of Infectious Disease, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Sullivan+K%22">Sullivan K</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Weingart+MF%22">Weingart MF</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Willmore+A%22">Willmore A</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Zhuo+H%22">Zhuo H</searchLink>; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+AJ%22">Rogers AJ</searchLink>; Division of Pulmonary and Critical Care, Department of Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Stringer+KA%22">Stringer KA</searchLink>; Department of Clinical Pharmacy, College of Pharmacy, and.; Division of Pulmonary and Critical Care Medicine and.; Weil Institute for Critical Care Research & Innovation, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Matthay+MA%22">Matthay MA</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.; Department of Anesthesia, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Calfee+CS%22">Calfee CS</searchLink>; Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.; Department of Anesthesia, UCSF, San Francisco, California, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Dec 02; Vol. 136 (3). <i>Date of Electronic Publication: </i>2025 Dec 02 (<i>Print Publication: </i>2026).
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