Human alveolar macrophage function is impaired in tuberculosis contacts with diabetes.

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Title: Human alveolar macrophage function is impaired in tuberculosis contacts with diabetes.
Authors: Kleynhans L; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia. Electronic address: leanie.kleynhans@mater.uq.edu.au., Kunsevi-Kilola C; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: kunsevicaryn@sun.ac.za., Tshivhula H; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: tshivhula@sun.ac.za., Webber T; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: twebber@sun.ac.za., Keyser A; Vaccines for Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Electronic address: alana.keyser@gmail.com., Prins N; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: nbprins@sun.ac.za., Snyders CI; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: cisnyders@sun.ac.za., Shabangu A; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: ayandas@sun.ac.za., Rozot V; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. Electronic address: virginie.rozot@uct.ac.za., Kidd M; Centre for Statistical Consultation, Stellenbosch University, Stellenbosch, South Africa. Electronic address: mkidd@sun.ac.za., Zhang H; Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: hzhangatus@gmail.com., Cai H; Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: hong.cai@utsa.edu., Wang Y; Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: Yufeng.Wang@utsa.edu., Ewing AD; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia. Electronic address: adam.ewing@mater.uq.edu.au., Malherbe ST; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: malherbe@sun.ac.za., Azad AK; Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: aazad@txbiomed.org., Arnett E; Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: earnett@txbiomed.org., Restrepo BI; Texas Biomedical Research Institute, San Antonio, TX, USA; Department of Epidemiology, School of Public Health-Brownsville Campus, University of Texas Health Science Center at Houston, Brownsville, TX, USA; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, USA. Electronic address: blanca.i.restrepo@uth.tmc.edu., Schlesinger LS; Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: lschlesinger@txbiomed.org., Ronacher K; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia. Electronic address: katharina.ronacher@mater.uq.edu.au.
Source: EBioMedicine [EBioMedicine] 2025 Dec; Vol. 122, pp. 106050. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Human alveolar macrophage function is impaired in tuberculosis contacts with diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Kleynhans+L%22">Kleynhans L</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia. Electronic address: leanie.kleynhans@mater.uq.edu.au.<br /><searchLink fieldCode="AU" term="%22Kunsevi-Kilola+C%22">Kunsevi-Kilola C</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: kunsevicaryn@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Tshivhula+H%22">Tshivhula H</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: tshivhula@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Webber+T%22">Webber T</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: twebber@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Keyser+A%22">Keyser A</searchLink>; Vaccines for Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Electronic address: alana.keyser@gmail.com.<br /><searchLink fieldCode="AU" term="%22Prins+N%22">Prins N</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: nbprins@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Snyders+CI%22">Snyders CI</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: cisnyders@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Shabangu+A%22">Shabangu A</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: ayandas@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Rozot+V%22">Rozot V</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. Electronic address: virginie.rozot@uct.ac.za.<br /><searchLink fieldCode="AU" term="%22Kidd+M%22">Kidd M</searchLink>; Centre for Statistical Consultation, Stellenbosch University, Stellenbosch, South Africa. Electronic address: mkidd@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: hzhangatus@gmail.com.<br /><searchLink fieldCode="AU" term="%22Cai+H%22">Cai H</searchLink>; Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: hong.cai@utsa.edu.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: Yufeng.Wang@utsa.edu.<br /><searchLink fieldCode="AU" term="%22Ewing+AD%22">Ewing AD</searchLink>; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia. Electronic address: adam.ewing@mater.uq.edu.au.<br /><searchLink fieldCode="AU" term="%22Malherbe+ST%22">Malherbe ST</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: malherbe@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Azad+AK%22">Azad AK</searchLink>; Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: aazad@txbiomed.org.<br /><searchLink fieldCode="AU" term="%22Arnett+E%22">Arnett E</searchLink>; Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: earnett@txbiomed.org.<br /><searchLink fieldCode="AU" term="%22Restrepo+BI%22">Restrepo BI</searchLink>; Texas Biomedical Research Institute, San Antonio, TX, USA; Department of Epidemiology, School of Public Health-Brownsville Campus, University of Texas Health Science Center at Houston, Brownsville, TX, USA; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, USA. Electronic address: blanca.i.restrepo@uth.tmc.edu.<br /><searchLink fieldCode="AU" term="%22Schlesinger+LS%22">Schlesinger LS</searchLink>; Texas Biomedical Research Institute, San Antonio, TX, USA. Electronic address: lschlesinger@txbiomed.org.<br /><searchLink fieldCode="AU" term="%22Ronacher+K%22">Ronacher K</searchLink>; DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia. Electronic address: katharina.ronacher@mater.uq.edu.au.
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