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Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy.

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Title: Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy.
Authors: Lai M; Department of Biostatistics, Boston University, Boston, MA, USA.; Faculty of Computing & Data Sciences, Boston University, Boston, MA, USA., Kim K; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Sungkyunkwan University School of Medicine, Suwon-si, Gyeonggi-do, South Korea., Zheng Y; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Castellani CA; Departments of Pathology and Laboratory Medicine & Epidemiology and Biostatistics, Western University, London, ON, Canada.; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ratliff SM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Wang M; Department of Biostatistics, Boston University, Boston, MA, USA., Liu X; Department of Biostatistics, Boston University, Boston, MA, USA., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Huan T; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Bonsu K; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Newcomb C; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., McKessy K; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Joehanes R; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Ma J; Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Manson JE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Grove ML; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Bressler J; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lappalainen T; New York Genome Center, New York, NY, USA.; Department of Systems Biology, Columbia University, New York, NY, USA., Kasela S; New York Genome Center, New York, NY, USA.; Department of Systems Biology, Columbia University, New York, NY, USA., Blackwell TW; TOPMed Informatics Research Center, University of Michigan, Ann Arbor, MI, USA., Lake NJ; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Ferrier KR; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Ekker SC; Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, TX, USA., Hou L; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Zhang K; Department of Population and Community Health, College of Public Health, The University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Fornage M; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA., Liu Y; Department of Medicine, Divisions of Cardiology and Neurology, Duke University Medical Center, Durham, NC, USA., Levy D; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; Framingham Heart Study, Framingham, MA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Liu C; Department of Biostatistics, Boston University, Boston, MA, USA. liuc@bu.edu.; Framingham Heart Study, Framingham, MA, USA. liuc@bu.edu.
Corporate Authors: NHLBI Trans-Omics for Precision Medicine (TOPMed) mtDNA Working Group
Source: Nature communications [Nat Commun] 2025 Dec 02; Vol. 16 (1), pp. 10962. Date of Electronic Publication: 2025 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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