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A CRISPR-based genome-wide loss-of-function screen defines a role of host metabolism in regulating hepatitis B virus infection.

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Title: A CRISPR-based genome-wide loss-of-function screen defines a role of host metabolism in regulating hepatitis B virus infection.
Authors: Inuzuka T; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; Department of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine, Kyoto, Japan., Mouzannar K; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Zhang M; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Umarova R; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Park SB; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Uchida T; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; Department of Gastroenterology and Hepatology, Oita University, Graduate School of Medicine, Oita, Japan; Division of Travel Medicine and Health, Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Oita, Japan., Ma CD; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA., Liang TJ; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA. Electronic address: jakel@bdg10.niddk.nih.gov.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Mar 04; Vol. 34 (3), pp. 1616-1632. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A CRISPR-based genome-wide loss-of-function screen defines a role of host metabolism in regulating hepatitis B virus infection.
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  Data: <searchLink fieldCode="AU" term="%22Inuzuka+T%22">Inuzuka T</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; Department of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Mouzannar+K%22">Mouzannar K</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Umarova+R%22">Umarova R</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Park+SB%22">Park SB</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Uchida+T%22">Uchida T</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA; Department of Gastroenterology and Hepatology, Oita University, Graduate School of Medicine, Oita, Japan; Division of Travel Medicine and Health, Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Oita, Japan.<br /><searchLink fieldCode="AU" term="%22Ma+CD%22">Ma CD</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Liang+TJ%22">Liang TJ</searchLink>; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA. Electronic address: jakel@bdg10.niddk.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Mar 04; Vol. 34 (3), pp. 1616-1632. <i>Date of Electronic Publication: </i>2025 Dec 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ymthe.2025.11.032
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        Text: English
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              Text: 2026 Mar 04
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