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Kidney Metabolism During Normothermic Machine Perfusion Differs Substantially From In Vivo Conditions.

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Title: Kidney Metabolism During Normothermic Machine Perfusion Differs Substantially From In Vivo Conditions.
Authors: Ogurlu B; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van Furth LA; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Zuo Y; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Hamelink TL; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van Klinken JB; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.; Core Facility Metabolomics, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.; Laboratory Genetic Metabolic Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands., Pamplona CC; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bennedsgaard SS; Department of Urology, Aarhus University Hospital, Aarhus, Denmark., van Leeuwen LL; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Recanati/Miller Transplantation Institute, Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York, NY., Lantinga VA; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Qi H; Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark., Pool MBF; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Vendrell I; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Kessler BM; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Fischer R; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Lin L; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Luo Y; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Jespersen B; Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Bakker BM; Laboratory of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Pietzner M; Health Data Modelling, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom., Leuvenink HGD; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Keller AK; Department of Urology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Moers C; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Source: Transplantation [Transplantation] 2026 Feb 01; Vol. 110 (2), pp. e405-e415. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE
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  Data: Kidney Metabolism During Normothermic Machine Perfusion Differs Substantially From In Vivo Conditions.
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  Data: <searchLink fieldCode="AU" term="%22Ogurlu+B%22">Ogurlu B</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Furth+LA%22">van Furth LA</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zuo+Y%22">Zuo Y</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hamelink+TL%22">Hamelink TL</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Klinken+JB%22">van Klinken JB</searchLink>; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.; Core Facility Metabolomics, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.; Laboratory Genetic Metabolic Diseases, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pamplona+CC%22">Pamplona CC</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bennedsgaard+SS%22">Bennedsgaard SS</searchLink>; Department of Urology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22van+Leeuwen+LL%22">van Leeuwen LL</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Recanati/Miller Transplantation Institute, Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York, NY.<br /><searchLink fieldCode="AU" term="%22Lantinga+VA%22">Lantinga VA</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Qi+H%22">Qi H</searchLink>; Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Pool+MBF%22">Pool MBF</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vendrell+I%22">Vendrell I</searchLink>; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kessler+BM%22">Kessler BM</searchLink>; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fischer+R%22">Fischer R</searchLink>; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jespersen+B%22">Jespersen B</searchLink>; Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22van+Dijk+KW%22">van Dijk KW</searchLink>; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bakker+BM%22">Bakker BM</searchLink>; Laboratory of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pietzner+M%22">Pietzner M</searchLink>; Health Data Modelling, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Leuvenink+HGD%22">Leuvenink HGD</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Keller+AK%22">Keller AK</searchLink>; Department of Urology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Moers+C%22">Moers C</searchLink>; Department of Surgery-Organ Donation and Transplantation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%220132144%22">Transplantation</searchLink> [Transplantation] 2026 Feb 01; Vol. 110 (2), pp. e405-e415. <i>Date of Electronic Publication: </i>2025 Dec 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0132144 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1534-6080 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200411337%22">00411337 </searchLink><i>NLM ISO Abbreviation: </i>Transplantation <i>Subsets: </i>MEDLINE
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