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Determinants of pleiotropy and monotonic gene dosage responses across human traits.

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Title: Determinants of pleiotropy and monotonic gene dosage responses across human traits.
Authors: Kazem S; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada., Kumar K; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada., Huguet G; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada., Mollon J; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA., Renne T; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada., Schultz LM; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia, and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA., Knowles EEM; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA., Engchuan W; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada., Shanta O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Thiruvahindrapuram B; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada., MacDonald JR; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada., Greenwood CMT; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, Departrment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada., Scherer SW; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Ontario, Canada., Almasy L; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia, and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA., Sebat J; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Glahn DC; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA., Dumas G; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Jacquemont S; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.
Source: Research square [Res Sq] 2025 Nov 19. Date of Electronic Publication: 2025 Nov 19.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kazem+S%22">Kazem S</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Kumar+K%22">Kumar K</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Huguet+G%22">Huguet G</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Mollon+J%22">Mollon J</searchLink>; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Renne+T%22">Renne T</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Schultz+LM%22">Schultz LM</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia, and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Knowles+EEM%22">Knowles EEM</searchLink>; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Engchuan+W%22">Engchuan W</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Shanta+O%22">Shanta O</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thiruvahindrapuram+B%22">Thiruvahindrapuram B</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22MacDonald+JR%22">MacDonald JR</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Greenwood+CMT%22">Greenwood CMT</searchLink>; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, Departrment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Scherer+SW%22">Scherer SW</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Almasy+L%22">Almasy L</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia, and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sebat+J%22">Sebat J</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Glahn+DC%22">Glahn DC</searchLink>; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dumas+G%22">Dumas G</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Jacquemont+S%22">Jacquemont S</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.
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