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Inhibiting sirtuin-dependent DNA repair and oxidative stress responses impairs DIPG cell survival.

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Title: Inhibiting sirtuin-dependent DNA repair and oxidative stress responses impairs DIPG cell survival.
Authors: King SA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Rheem R; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Spitler KM; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., O'Leary BR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Graham CH; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Solst SR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Teesch LM; High Resolution Mass Spectrometry Facility, University of Iowa, Iowa City, IA, USA., Sho S; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Byrne JD; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA., Spitz DR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA., Howard ME; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Source: Research square [Res Sq] 2025 Nov 21. Date of Electronic Publication: 2025 Nov 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22King+SA%22">King SA</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Rheem+R%22">Rheem R</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Spitler+KM%22">Spitler KM</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22O'Leary+BR%22">O'Leary BR</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Graham+CH%22">Graham CH</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Solst+SR%22">Solst SR</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Teesch+LM%22">Teesch LM</searchLink>; High Resolution Mass Spectrometry Facility, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Sho+S%22">Sho S</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Byrne+JD%22">Byrne JD</searchLink>; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.<br /><searchLink fieldCode="AU" term="%22Spitz+DR%22">Spitz DR</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Howard+ME%22">Howard ME</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101768035%22">Research square</searchLink> [Res Sq] 2025 Nov 21. <i>Date of Electronic Publication: </i>2025 Nov 21.
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              Text: 2025 Nov 21
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