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A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice.

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Title: A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice.
Authors: Conde E; Institut Pasteur, Université Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France.; Neovacs SA, 92150 Suresnes, France.; Sorbonne Université, College Doctoral, 75006 Paris, France., Lamanna E; Institut Pasteur, Université Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France.; Neovacs SA, 92150 Suresnes, France., Mougel A; Neovacs SA, 92150 Suresnes, France.; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Kamphuis JBJ; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Loste A; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Stackowicz J; Institut Pasteur, Université Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France.; Sorbonne Université, College Doctoral, 75006 Paris, France., Godon O; Institut Pasteur, Université Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France., Mauré E; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Pecalvel C; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Worrall WPM; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Andrieux L; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Leveque E; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Benmessaoud Z; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France., Apoil PA; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France.; Institut Fédératif de Biologie, University Hospital Centre of Toulouse, 31024 Toulouse, France., Backovic M; Institut Pasteur, Université Paris Cité, CNRS UMR3569, Unité de Virologie Structurale, 75015 Paris, France., Iannascoli B; Institut Pasteur, Université Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France., Bonnefoy J; Neovacs SA, 92150 Suresnes, France., Hamdi S; Neovacs SA, 92150 Suresnes, France., Colaone F; Neovacs SA, 92150 Suresnes, France., Jönsson F; Institut Pasteur, Université Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France.; CNRS, 75015 Paris, France., England P; Institut Pasteur, Université Paris Cité, CNRS UMR3528, Plateforme de Biophysique Moléculaire, 75015 Paris, France., Guilleminault L; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France.; Department of Respiratory Medicine, Toulouse University Hospital, Faculty of Medicine, 31024 Toulouse, France., Malissen B; Centre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France., Fiore F; Centre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France., Linnemann L; Helminth Immunology Group, Section Interface, Bernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany., Breloer M; Helminth Immunology Group, Section Interface, Bernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.; Department of Biology, University Hamburg, 20148 Hamburg, Germany., Gaudenzio N; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France.; Genoskin SAS, 31100 Toulouse, France., Drouet B; Neovacs SA, 92150 Suresnes, France., Lemdani K; Neovacs SA, 92150 Suresnes, France., Serra V; Neovacs SA, 92150 Suresnes, France., Bruhns P; Institut Pasteur, Université Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, France., Reber LL; Neovacs SA, 92150 Suresnes, France.; University of Toulouse, Infinity, Inserm, CNRS, 31024 Toulouse, France.
Source: Science translational medicine [Sci Transl Med] 2025 Dec 03; Vol. 17 (827), pp. eads0982. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.ads0982