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Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits.

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Title: Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits.
Authors: Alkhawaja AA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Currin KW; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Perrin HJ; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Vadlamudi S; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Etheridge AS; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC 27599, USA., Broadaway KA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Cannon GH; Advanced Analytics Core, University of North Carolina, Chapel Hill, NC 27599, USA., Anderson CW; Advanced Analytics Core, University of North Carolina, Chapel Hill, NC 27599, USA., Moxley AH; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Iuga AC; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA., Schuetz EG; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Innocenti F; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC 27599, USA., Furey TS; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: mohlke@med.unc.edu.
Source: American journal of human genetics [Am J Hum Genet] 2026 Jan 08; Vol. 113 (1), pp. 133-148. Date of Electronic Publication: 2025 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Alkhawaja+AA%22">Alkhawaja AA</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Currin+KW%22">Currin KW</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Perrin+HJ%22">Perrin HJ</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Vadlamudi+S%22">Vadlamudi S</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Etheridge+AS%22">Etheridge AS</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Broadaway+KA%22">Broadaway KA</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Cannon+GH%22">Cannon GH</searchLink>; Advanced Analytics Core, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+CW%22">Anderson CW</searchLink>; Advanced Analytics Core, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Moxley+AH%22">Moxley AH</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Iuga+AC%22">Iuga AC</searchLink>; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Schuetz+EG%22">Schuetz EG</searchLink>; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Innocenti+F%22">Innocenti F</searchLink>; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Furey+TS%22">Furey TS</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Mohlke+KL%22">Mohlke KL</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: mohlke@med.unc.edu.
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  Data: <searchLink fieldCode="JN" term="%220370475%22">American journal of human genetics</searchLink> [Am J Hum Genet] 2026 Jan 08; Vol. 113 (1), pp. 133-148. <i>Date of Electronic Publication: </i>2025 Dec 02.
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