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Chemical Optimization of Cerebral Embolectomy 2 (CHOICE 2) trial: study protocol.

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Title: Chemical Optimization of Cerebral Embolectomy 2 (CHOICE 2) trial: study protocol.
Authors: Renú A; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain., de la Riva P; Neurology, Donostia Ospitalea, San Sebastián, Basque Country, Spain., Delgado-Mederos R; Neurology, Son Espases University Hospital, Palma Mallorca, Balearic Island, Spain., Dorado L; Department of Neurology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain., Fernandez-Couto MD; Neurology, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain., Herrera-Isasi M; Complejo Hospitalario de Navarra, Pamplona, Navarre, Spain., López Hernández N; Neurology, Dr Balmis General University Hospital, Alicante, Valencian Community, Spain., Morales A; Neurology, Virgen de la Arrixaca University Hospital, El Palmar, Región de Murcia, Spain., Morales-Caba L; Interventional Neuroradiology, La Fe University and Polytechnic Hospital, Valencia, Spain., Camps-Renom P; Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Singla A; Avania Europe-Barcelona, Barcelona, Spain., Terceño M; Neurology, Hospital Universitari de Girona Doctor Josep Trueta Servei de Neurologia, Girona, Girona, Spain., Vega P; Radiology, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain., Amaro S; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain., Blasco J; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Neurointerventional Department, Hospital Clinic de Barcelona Centre de Diagnostic Biomedic, Barcelona, Spain., Laredo C; Magnetic Resonance Imaging Core Facility, August Pi i Sunyer Institute of Biomedical Research, Barcelona, Spain., Leira EC; Neurology, University of Iowa Health Care, Iowa City, Iowa, USA., Oleaga L; Radiology, Hospital Clinic de Barcelona Centre de Diagnostic per la Imatge Clinic, Barcelona, Spain., Serena J; Neurology, Doctor Josep Trueta University Hospital of Girona, Girona, Spain., Urra X; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain., Werner M; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Neurointerventional Department, Hospital Clinic de Barcelona Centre de Diagnostic Biomedic, Barcelona, Spain., Hernández Fernández F; Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Castilla-La Mancha, Spain., Valls J; Biostatistics and Epidemiology Unit, Autonomous University of Barcelona, Barcelona, Spain., Arenillas Lara JF; Neurology, Hospital Clinico Universitario de Valladolid, Valladolid, Spain., Freijo MDM; Neurology, Cruces University Hospital, Barakaldo, Basque Country, Spain., Pérez de la Ossa N; Neurology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain., San Roman L; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Neurointerventional Department, Hospital Clinic de Barcelona Centre de Diagnostic Biomedic, Barcelona, Spain., Torres F; Medical Statistics Core Facility, Clinical Pharmacology Service, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.; Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain., Castellanos M; Neurology, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain., Davalos A; Neuroscience, Autonomous University of Barcelona, Barcelona, Spain., Chamorro A; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain achamorro@clinic.cat.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain.
Corporate Authors: CHOICE 2 Investigators
Source: Stroke and vascular neurology [Stroke Vasc Neurol] 2025 Dec 03. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Country of Publication: England NLM ID: 101689996 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-8696 (Electronic) Linking ISSN: 20598688 NLM ISO Abbreviation: Stroke Vasc Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemical Optimization of Cerebral Embolectomy 2 (CHOICE 2) trial: study protocol.
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  Data: <searchLink fieldCode="AU" term="%22Renú+A%22">Renú A</searchLink>; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22de+la+Riva+P%22">de la Riva P</searchLink>; Neurology, Donostia Ospitalea, San Sebastián, Basque Country, Spain.<br /><searchLink fieldCode="AU" term="%22Delgado-Mederos+R%22">Delgado-Mederos R</searchLink>; Neurology, Son Espases University Hospital, Palma Mallorca, Balearic Island, Spain.<br /><searchLink fieldCode="AU" term="%22Dorado+L%22">Dorado L</searchLink>; Department of Neurology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez-Couto+MD%22">Fernandez-Couto MD</searchLink>; Neurology, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Herrera-Isasi+M%22">Herrera-Isasi M</searchLink>; Complejo Hospitalario de Navarra, Pamplona, Navarre, Spain.<br /><searchLink fieldCode="AU" term="%22López+Hernández+N%22">López Hernández N</searchLink>; Neurology, Dr Balmis General University Hospital, Alicante, Valencian Community, Spain.<br /><searchLink fieldCode="AU" term="%22Morales+A%22">Morales A</searchLink>; Neurology, Virgen de la Arrixaca University Hospital, El Palmar, Región de Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Morales-Caba+L%22">Morales-Caba L</searchLink>; Interventional Neuroradiology, La Fe University and Polytechnic Hospital, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Camps-Renom+P%22">Camps-Renom P</searchLink>; Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Singla+A%22">Singla A</searchLink>; Avania Europe-Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Terceño+M%22">Terceño M</searchLink>; Neurology, Hospital Universitari de Girona Doctor Josep Trueta Servei de Neurologia, Girona, Girona, Spain.<br /><searchLink fieldCode="AU" term="%22Vega+P%22">Vega P</searchLink>; Radiology, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.<br /><searchLink fieldCode="AU" term="%22Amaro+S%22">Amaro S</searchLink>; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Blasco+J%22">Blasco J</searchLink>; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Neurointerventional Department, Hospital Clinic de Barcelona Centre de Diagnostic Biomedic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Laredo+C%22">Laredo C</searchLink>; Magnetic Resonance Imaging Core Facility, August Pi i Sunyer Institute of Biomedical Research, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Leira+EC%22">Leira EC</searchLink>; Neurology, University of Iowa Health Care, Iowa City, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Oleaga+L%22">Oleaga L</searchLink>; Radiology, Hospital Clinic de Barcelona Centre de Diagnostic per la Imatge Clinic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Serena+J%22">Serena J</searchLink>; Neurology, Doctor Josep Trueta University Hospital of Girona, Girona, Spain.<br /><searchLink fieldCode="AU" term="%22Urra+X%22">Urra X</searchLink>; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Werner+M%22">Werner M</searchLink>; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Neurointerventional Department, Hospital Clinic de Barcelona Centre de Diagnostic Biomedic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hernández+Fernández+F%22">Hernández Fernández F</searchLink>; Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Castilla-La Mancha, Spain.<br /><searchLink fieldCode="AU" term="%22Valls+J%22">Valls J</searchLink>; Biostatistics and Epidemiology Unit, Autonomous University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arenillas+Lara+JF%22">Arenillas Lara JF</searchLink>; Neurology, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.<br /><searchLink fieldCode="AU" term="%22Freijo+MDM%22">Freijo MDM</searchLink>; Neurology, Cruces University Hospital, Barakaldo, Basque Country, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez+de+la+Ossa+N%22">Pérez de la Ossa N</searchLink>; Neurology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22San+Roman+L%22">San Roman L</searchLink>; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain.; Neurointerventional Department, Hospital Clinic de Barcelona Centre de Diagnostic Biomedic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Torres+F%22">Torres F</searchLink>; Medical Statistics Core Facility, Clinical Pharmacology Service, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.; Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castellanos+M%22">Castellanos M</searchLink>; Neurology, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Davalos+A%22">Davalos A</searchLink>; Neuroscience, Autonomous University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Chamorro+A%22">Chamorro A</searchLink>; Comprehensive Stroke Center, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain achamorro@clinic.cat.; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), August Pi i Sunyer Institute of Biomedical Research, Barcelona, Barcelona, Spain.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ%22">BMJ </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101689996 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-8696 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220598688%22">20598688 </searchLink><i>NLM ISO Abbreviation: </i>Stroke Vasc Neurol <i>Subsets: </i>MEDLINE
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