The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells.

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Title: The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells.
Authors: Son SW; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea., Lee HJ; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Kang N; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea., Bae S; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea., Cho E; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea., Kwon H; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Yoon DY; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Lee C; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Lee S; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Son MK; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Chae J; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Kim S; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea., Oh SJ; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Sim Y; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea., Lee KM; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea., Yee C; Department of Melanoma Medical Oncology and Immunology, U.T. MD Anderson Cancer Center, Houston, TX, USA., Woo SR; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea., Jeong YJ; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea., Choi HJ; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.; Jin BioCell Co. Ltd. R&D Center, Yangsan, South Korea., Kwak JY; Department of Pharmacology, School of Medicine, Ajou University, Suwon, South Korea., Lee EW; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea., Park J; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.; Department of Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea., Kwak SG; Department of Medical Statistics, Daegu Catholic University School of Medicine, Daegu, South Korea., Chang YC; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea. ycchang@cu.ac.kr., Kim TW; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea. twkim0421@korea.ac.kr.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea. twkim0421@korea.ac.kr.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea. twkim0421@korea.ac.kr., Song KH; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea. khsong@cu.ac.kr.
Source: Nature communications [Nat Commun] 2025 Dec 03; Vol. 16 (1), pp. 10849. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells.
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  Data: <searchLink fieldCode="AU" term="%22Son+SW%22">Son SW</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HJ%22">Lee HJ</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kang+N%22">Kang N</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Bae+S%22">Bae S</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Cho+E%22">Cho E</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+H%22">Kwon H</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+DY%22">Yoon DY</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+C%22">Lee C</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Son+MK%22">Son MK</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Chae+J%22">Chae J</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Oh+SJ%22">Oh SJ</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Sim+Y%22">Sim Y</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+KM%22">Lee KM</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Yee+C%22">Yee C</searchLink>; Department of Melanoma Medical Oncology and Immunology, U.T. MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Woo+SR%22">Woo SR</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+YJ%22">Jeong YJ</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Choi+HJ%22">Choi HJ</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.; Jin BioCell Co. Ltd. R&D Center, Yangsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwak+JY%22">Kwak JY</searchLink>; Department of Pharmacology, School of Medicine, Ajou University, Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+EW%22">Lee EW</searchLink>; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea.; Department of Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwak+SG%22">Kwak SG</searchLink>; Department of Medical Statistics, Daegu Catholic University School of Medicine, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Chang+YC%22">Chang YC</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea. ycchang@cu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Kim+TW%22">Kim TW</searchLink>; Department of Biochemistry and Molecular Biology, Korea university College of Medicine, Seoul, South Korea. twkim0421@korea.ac.kr.; Department of Convergence Medicine, College of Medicine, Korea University, Seoul, South Korea. twkim0421@korea.ac.kr.; BK21 Graduate Program, Department of Biomedical Science, Korea university College of Medicine, Seoul, South Korea. twkim0421@korea.ac.kr.<br /><searchLink fieldCode="AU" term="%22Song+KH%22">Song KH</searchLink>; Department of Cell biology, Daegu Catholic University School of Medicine, Daegu, South Korea. khsong@cu.ac.kr.
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