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TSC tunes progenitor balance and upper-layer neuron generation in neocortex.

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Title: TSC tunes progenitor balance and upper-layer neuron generation in neocortex.
Authors: Casingal CR; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Nakagawa N; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Laboratory of Developmental Neurobiology, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yabuno-Nakagawa K; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Meyer C; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Liu S; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Gkini V; Neuroscience Center, HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Cho SJ; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Skarica M; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Liang D; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Simon JM; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Matoba N; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Mallick A; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Singla R; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Park J; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Huang CW; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Wilson H; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Lee J; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Ghashghaei HT; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA., Stuber GD; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA., Heikinheimo O; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Namba T; Neuroscience Center, HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Developmental Biology, Fujita Health University School of Medicine; Division of Developmental Biology, International Center for Brain Science (ICBS), Fujita Health University, Toyoake, Japan., Stein JL; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Anton ES; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA. anton@med.unc.edu.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. anton@med.unc.edu.
Source: Nature [Nature] 2026 Feb; Vol. 650 (8101), pp. 417-427. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TSC tunes progenitor balance and upper-layer neuron generation in neocortex.
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  Data: <searchLink fieldCode="AU" term="%22Casingal+CR%22">Casingal CR</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Nakagawa+N%22">Nakagawa N</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Laboratory of Developmental Neurobiology, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yabuno-Nakagawa+K%22">Yabuno-Nakagawa K</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+C%22">Meyer C</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gkini+V%22">Gkini V</searchLink>; Neuroscience Center, HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Cho+SJ%22">Cho SJ</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Skarica+M%22">Skarica M</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Liang+D%22">Liang D</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Simon+JM%22">Simon JM</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, T. 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Chan School of Public Health, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Matoba+N%22">Matoba N</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mallick+A%22">Mallick A</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Singla+R%22">Singla R</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Huang+CW%22">Huang CW</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+H%22">Wilson H</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ghashghaei+HT%22">Ghashghaei HT</searchLink>; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.<br /><searchLink fieldCode="AU" term="%22Stuber+GD%22">Stuber GD</searchLink>; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Heikinheimo+O%22">Heikinheimo O</searchLink>; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Namba+T%22">Namba T</searchLink>; Neuroscience Center, HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Developmental Biology, Fujita Health University School of Medicine; Division of Developmental Biology, International Center for Brain Science (ICBS), Fujita Health University, Toyoake, Japan.<br /><searchLink fieldCode="AU" term="%22Stein+JL%22">Stein JL</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Anton+ES%22">Anton ES</searchLink>; UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA. anton@med.unc.edu.; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. anton@med.unc.edu.
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