Analysis of experimental colorectal liver metastases identifies distinct proliferation-independent transcriptional programs in micro- versus macrometastases.

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Title: Analysis of experimental colorectal liver metastases identifies distinct proliferation-independent transcriptional programs in micro- versus macrometastases.
Authors: Peters NA; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Heinz MC; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Küçükköse E; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Viergever BJ; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Baars M; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Amini M; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Huismans MA; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Andel D; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Verheem A; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Vercoulen Y; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Center for Molecular Medicine, UCyTOF, University Medical Center Utrecht, Utrecht, The Netherlands., Snippert H; Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Borel Rinkes IHM; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kranenburg O; Division of Imaging and Cancer, Lab Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. o.kranenburg@umcutrecht.nl.
Source: Journal of translational medicine [J Transl Med] 2025 Dec 03; Vol. 24 (1), pp. 37. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-025-07218-3