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Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age.

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Title: Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age.
Authors: Ramírez-Pardo I; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Campanario S; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Chavda B; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA., Santiago-Fernández O; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA., Flández M; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Escuelab Innovación Educativa, Madrid, Spain.; Faculty of Experimental Sciences, Francisco de Vitoria University (UFV), Pozuelo de Alarcón, Spain., Grima-Terrén M; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Cisneros A; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA., Calls-Cobos A; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA., Itzhak DN; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Ngo B; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Janaki-Raman S; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Kantz ED; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Ortet L; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain., Diaz A; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA., Lindenau K; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA., Doménech-Fernández J; Servicio de Cirugía Ortopédica y Traumatología, Hospital Arnau de Vilanova, Valencia, Spain.; Department of Orthopedic Surgery, Clinica Universidad de Navarra, Pamplona, Spain., Gómez-Cabrera MC; Freshage Research Group, Department of Physiology, University of Valencia and CIBERFES. Fundación Investigación Hospital Clínico/INCLIVA, Valencia, Spain., Camafeita E; Laboratory of Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Vázquez J; Laboratory of Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain., Martinez-Vicente M; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR) Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain., Serrano AL; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA., Perdiguero E; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA., Isern J; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Cuervo AM; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA. ana-maria.cuervo@einsteinmed.edu.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA. ana-maria.cuervo@einsteinmed.edu., Muñoz-Cánoves P; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain. pmunozcanoves@altoslabs.com.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA. pmunozcanoves@altoslabs.com.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. pmunozcanoves@altoslabs.com.; ICREA, Barcelona, Spain. pmunozcanoves@altoslabs.com.
Source: Nature metabolism [Nat Metab] 2025 Dec; Vol. 7 (12), pp. 2571-2588. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age.
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  Data: <searchLink fieldCode="AU" term="%22Ramírez-Pardo+I%22">Ramírez-Pardo I</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Campanario+S%22">Campanario S</searchLink>; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Chavda+B%22">Chavda B</searchLink>; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Santiago-Fernández+O%22">Santiago-Fernández O</searchLink>; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Flández+M%22">Flández M</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Escuelab Innovación Educativa, Madrid, Spain.; Faculty of Experimental Sciences, Francisco de Vitoria University (UFV), Pozuelo de Alarcón, Spain.<br /><searchLink fieldCode="AU" term="%22Grima-Terrén+M%22">Grima-Terrén M</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cisneros+A%22">Cisneros A</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Calls-Cobos+A%22">Calls-Cobos A</searchLink>; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Itzhak+DN%22">Itzhak DN</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ngo+B%22">Ngo B</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Janaki-Raman+S%22">Janaki-Raman S</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kantz+ED%22">Kantz ED</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ortet+L%22">Ortet L</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Diaz+A%22">Diaz A</searchLink>; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lindenau+K%22">Lindenau K</searchLink>; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Doménech-Fernández+J%22">Doménech-Fernández J</searchLink>; Servicio de Cirugía Ortopédica y Traumatología, Hospital Arnau de Vilanova, Valencia, Spain.; Department of Orthopedic Surgery, Clinica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Cabrera+MC%22">Gómez-Cabrera MC</searchLink>; Freshage Research Group, Department of Physiology, University of Valencia and CIBERFES. Fundación Investigación Hospital Clínico/INCLIVA, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Camafeita+E%22">Camafeita E</searchLink>; Laboratory of Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vázquez+J%22">Vázquez J</searchLink>; Laboratory of Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Vicente+M%22">Martinez-Vicente M</searchLink>; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR) Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Serrano+AL%22">Serrano AL</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Perdiguero+E%22">Perdiguero E</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Isern+J%22">Isern J</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cuervo+AM%22">Cuervo AM</searchLink>; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA. ana-maria.cuervo@einsteinmed.edu.; Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA. ana-maria.cuervo@einsteinmed.edu.<br /><searchLink fieldCode="AU" term="%22Muñoz-Cánoves+P%22">Muñoz-Cánoves P</searchLink>; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain. pmunozcanoves@altoslabs.com.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA, USA. pmunozcanoves@altoslabs.com.; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. pmunozcanoves@altoslabs.com.; ICREA, Barcelona, Spain. pmunozcanoves@altoslabs.com.
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