How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factors.

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Title: How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factors.
Authors: Wieringa A; Department of Clinical Pharmacy, Isala Hospital, Zwolle, The Netherlands; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: A.Wieringa@isala.nl., Smeets TJL; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands., Ter Horst PGJ; Department of Clinical Pharmacy, Isala Hospital, Zwolle, The Netherlands., Hunfeld NGM; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands., Bellomo R; Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia; Department of Critical Care, School of Medicine, University of Melbourne, Parkville, Victoria, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Victoria, Australia., Prowle JR; Adult Critical Care Unit, The Royal London Hospital, Barts Health National Health Service Trust, London, United Kingdom; William Harvey Research Institute, Queen Mary University of London, London, United Kingdom; Department of Renal Medicine and Transplantation, The Royal London Hospital, Barts Health National Health Service Trust, London, United Kingdom., Elderman JH; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands., Valkenburg AJ; Department of Intensive Care, Isala Hospital, Zwolle, The Netherlands., Gommers D; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands., Zeitlinger M; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Tängdén T; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden., Abdul-Aziz MH; Faculty of Medicine, University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia., Li J; Infection Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Sikma MA; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Dutch Poisons Information Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Mangalore RP; Department of Infectious Diseases, Alfred Health, Melbourne, Victoria, Australia; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Stocker SL; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia; Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Sydney, New South Wales, Australia; St. Vincent's Clinical Campus, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia; Pharmacy Department, Blacktown Hospital, Blacktown, Sydney, New South Wales, Australia; Sydney Musculoskeletal Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, New South Wales, Australia., Endeman H; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands., Koch BCP; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Erasmus University Medical Center, Rotterdam, The Netherlands., Haringman JJ; Department of Intensive Care, Isala Hospital, Zwolle, The Netherlands.
Corporate Authors: Pharmacokinetics & Pharmacodynamics Anti-Infective Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EPASG), Acute Kidney Injury section of the European Society of Intensive Care Medicine (ESICM), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT), Infections in the Intensive Care Unit, Sepsis, and Anti-Infective Pharmacology Working Group of International Society of Antimicrobial Chemotherapy (ISAC)
Source: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2026 Apr; Vol. 32 (4), pp. 560-571. Date of Electronic Publication: 2025 Dec 02.
Publication Type: Journal Article; Scoping Review; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE
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  Data: How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factors.
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  Data: <searchLink fieldCode="AU" term="%22Wieringa+A%22">Wieringa A</searchLink>; Department of Clinical Pharmacy, Isala Hospital, Zwolle, The Netherlands; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: A.Wieringa@isala.nl.<br /><searchLink fieldCode="AU" term="%22Smeets+TJL%22">Smeets TJL</searchLink>; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ter+Horst+PGJ%22">Ter Horst PGJ</searchLink>; Department of Clinical Pharmacy, Isala Hospital, Zwolle, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hunfeld+NGM%22">Hunfeld NGM</searchLink>; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bellomo+R%22">Bellomo R</searchLink>; Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia; Department of Critical Care, School of Medicine, University of Melbourne, Parkville, Victoria, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Prowle+JR%22">Prowle JR</searchLink>; Adult Critical Care Unit, The Royal London Hospital, Barts Health National Health Service Trust, London, United Kingdom; William Harvey Research Institute, Queen Mary University of London, London, United Kingdom; Department of Renal Medicine and Transplantation, The Royal London Hospital, Barts Health National Health Service Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Elderman+JH%22">Elderman JH</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Valkenburg+AJ%22">Valkenburg AJ</searchLink>; Department of Intensive Care, Isala Hospital, Zwolle, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gommers+D%22">Gommers D</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zeitlinger+M%22">Zeitlinger M</searchLink>; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Tängdén+T%22">Tängdén T</searchLink>; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Abdul-Aziz+MH%22">Abdul-Aziz MH</searchLink>; Faculty of Medicine, University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Infection Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sikma+MA%22">Sikma MA</searchLink>; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Dutch Poisons Information Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mangalore+RP%22">Mangalore RP</searchLink>; Department of Infectious Diseases, Alfred Health, Melbourne, Victoria, Australia; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Stocker+SL%22">Stocker SL</searchLink>; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia; Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Sydney, New South Wales, Australia; St. Vincent's Clinical Campus, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia; Pharmacy Department, Blacktown Hospital, Blacktown, Sydney, New South Wales, Australia; Sydney Musculoskeletal Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Endeman+H%22">Endeman H</searchLink>; Department of Intensive Care, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Koch+BCP%22">Koch BCP</searchLink>; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Haringman+JJ%22">Haringman JJ</searchLink>; Department of Intensive Care, Isala Hospital, Zwolle, The Netherlands.
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