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Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration.

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Title: Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration.
Authors: Kaluski-Kopatch S; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel., Stein D; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel., Venzor AG; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel., Ferreira Campos AM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Planque M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Goldstein B; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., De Allende-Becerra E; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Smirnov D; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.; Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, Russia., Zaretsky A; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel., Eremenko E; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel., Portillo M; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel., Einav M; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Krejci AB; Faculty of Science, University of South Bohemia, Ceske Budejovice, Czechia., Abdu U; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Khrameeva E; Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, Russia., Gitler D; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Toiber D; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. toiber@bgu.ac.il.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel. toiber@bgu.ac.il.
Source: Nature communications [Nat Commun] 2025 Dec 04; Vol. 17 (1), pp. 320. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration.
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  Data: <searchLink fieldCode="AU" term="%22Kaluski-Kopatch+S%22">Kaluski-Kopatch S</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Stein+D%22">Stein D</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Venzor+AG%22">Venzor AG</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Ferreira+Campos+AM%22">Ferreira Campos AM</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Planque+M%22">Planque M</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Goldstein+B%22">Goldstein B</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22De+Allende-Becerra+E%22">De Allende-Becerra E</searchLink>; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Smirnov+D%22">Smirnov D</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.; Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Zaretsky+A%22">Zaretsky A</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Eremenko+E%22">Eremenko E</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Portillo+M%22">Portillo M</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Einav+M%22">Einav M</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Krejci+AB%22">Krejci AB</searchLink>; Faculty of Science, University of South Bohemia, Ceske Budejovice, Czechia.<br /><searchLink fieldCode="AU" term="%22Abdu+U%22">Abdu U</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Khrameeva+E%22">Khrameeva E</searchLink>; Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Gitler+D%22">Gitler D</searchLink>; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel.; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Fendt+SM%22">Fendt SM</searchLink>; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Toiber+D%22">Toiber D</searchLink>; Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. toiber@bgu.ac.il.; School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer Sheva, Israel. toiber@bgu.ac.il.
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