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Cardiovascular-Kidney Effects of Dapagliflozin in Patients at Cardiovascular Risk With or Without Type 2 Diabetes: Results of a Randomized, Double-Blind, Placebo-Controlled Trial.

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Title: Cardiovascular-Kidney Effects of Dapagliflozin in Patients at Cardiovascular Risk With or Without Type 2 Diabetes: Results of a Randomized, Double-Blind, Placebo-Controlled Trial.
Authors: Sridhar VS; Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, Canada (V.S.S.).; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada., Kugathasan L; Division of Nephrology, Department of Medicine (L.K., Y.L., H.L., J.T., M.N., R.C.Y.L., D.Z.I.C.), University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada., Lytvyn Y; Division of Nephrology, Department of Medicine (L.K., Y.L., H.L., J.T., M.N., R.C.Y.L., D.Z.I.C.), University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada., Deng Y; Biostatistics Department (Y.D., L.E.L.), University Health Network, Toronto, Ontario, Canada., Liu H; Division of Nephrology, Department of Medicine (L.K., Y.L., H.L., J.T., M.N., R.C.Y.L., D.Z.I.C.), University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada., Lovblom LE; Biostatistics Department (Y.D., L.E.L.), University Health Network, Toronto, Ontario, Canada.; Institute of Health Policy, Management and Evaluation (L.E.L.), University of Toronto, Ontario, Canada., Tse J; Division of Nephrology, Department of Medicine (L.K., Y.L., H.L., J.T., M.N., R.C.Y.L., D.Z.I.C.), University Health Network, Toronto, Ontario, Canada., Nardone M; Division of Nephrology, Department of Medicine (L.K., Y.L., H.L., J.T., M.N., R.C.Y.L., D.Z.I.C.), University Health Network, Toronto, Ontario, Canada., Floras JS; Division of Cardiology, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada (J.S.F., T.O., T.T.)., Osuntokun T; Division of Cardiology, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada (J.S.F., T.O., T.T.)., Tobushi T; Division of Cardiology, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada (J.S.F., T.O., T.T.)., Lam RCY; Division of Nephrology, Department of Medicine (L.K., Y.L., H.L., J.T., M.N., R.C.Y.L., D.Z.I.C.), University Health Network, Toronto, Ontario, Canada., Lam B; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada., Stevens J; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, the Netherlands (J.S., D.J.T., H.J.L.H.)., Burger D; Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada (D.B.)., Touw DJ; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, the Netherlands (J.S., D.J.T., H.J.L.H.)., Heerspink HJL; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, the Netherlands (J.S., D.J.T., H.J.L.H.)., Lovshin JA; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine (J.A.L., B.A.P.), University of Toronto, Ontario, Canada.; Department of Medicine, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (J.A.L.)., Perkins BA; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Department of Medicine (J.A.L., B.A.P.), University of Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada (B.A.P.)., Cherney DZI; Division of Nephrology, Department of Medicine (L.K., Y.L., H.L., J.T., M.N., R.C.Y.L., D.Z.I.C.), University Health Network, Toronto, Ontario, Canada.; Department of Medicine, Temerty Faculty of Medicine (V.S.S., L.K., Y.L., H.L., B.L., J.A.L., B.A.P., D.Z.I.C.), University of Toronto, Ontario, Canada.
Source: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2026 Feb; Vol. 83 (2), pp. e25955. Date of Electronic Publication: 2025 Dec 05.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
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  Data: Cardiovascular-Kidney Effects of Dapagliflozin in Patients at Cardiovascular Risk With or Without Type 2 Diabetes: Results of a Randomized, Double-Blind, Placebo-Controlled Trial.
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  Data: <searchLink fieldCode="JN" term="%227906255%22">Hypertension (Dallas, Tex. : 1979)</searchLink> [Hypertension] 2026 Feb; Vol. 83 (2), pp. e25955. <i>Date of Electronic Publication: </i>2025 Dec 05.
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