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Aficamten in Obstructive Hypertrophic Cardiomyopathy: A Multidomain, Patient-Level Analysis of the MAPLE-HCM Trial.

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Title: Aficamten in Obstructive Hypertrophic Cardiomyopathy: A Multidomain, Patient-Level Analysis of the MAPLE-HCM Trial.
Authors: Wang A; Duke University Medical Center, Durham, North Carolina, USA. Electronic address: a.wang@duke.edu., Garcia-Pavia P; Hospital Universitario Puerta de Hierro de Majadahonda, IDIPHISA, CIBERCV, Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Masri A; Oregon Health Science University, Portland, Oregon, USA., Merkely B; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Nassif ME; University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA., Peña-Peña ML; General Hospital of H.U. Virgen Del Rocio, Seville, Spain., Barriales-Villa R; Complexo Hospitalario Universitario A Coruña, INIBIC, CIBERCV-ISCIII, A Coruña, Spain., Bilen O; Emory University Medical Center, Atlanta, Georgia, USA., Burroughs M; Wellstar Center for Cardiovascular Care, Hiram, Georgia, USA., Claggett BL; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Costabel JP; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., de Barros Correia E; Dante Pazzanese Institute of Cardiology, São Paulo, Brazil., Dybro A; Aarhus Hospital University, Aarhus, Denmark., Elliott P; Department of Inherited Cardiovascular Diseases, St Bartholomew's Hospital and Institute of Cardiovascular Science, University College London, London, United Kingdom., Hegde SM; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; University of Texas Southwestern Medical Center, Dallas, Texas, USA., Kulac IJ; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Lakdawala NK; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Lewis GD; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mann A; Colorado Springs, Colorado, USA., Nair A; Texas Heart Institute at Baylor College of Medicine, Houston, Texas, USA., Poulsen SH; Aarhus Hospital University, Aarhus, Denmark., Reant P; University Hospital Center of Bordeaux, University of Bordeaux, Bordeaux, France., Schulze PC; University Hospital Jena, Friedrich-Schiller-University, Jena, Germany., Solomon SD; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sohn R; Cytokinetics, Incorporated, South San Francisco, California, USA., Berhane I; Cytokinetics, Incorporated, South San Francisco, California, USA., Heitner SB; Cytokinetics, Incorporated, South San Francisco, California, USA., Jacoby DL; Cytokinetics, Incorporated, South San Francisco, California, USA., Kupfer S; Cytokinetics, Incorporated, South San Francisco, California, USA., Malik FI; Cytokinetics, Incorporated, South San Francisco, California, USA., Wohltman A; Cytokinetics, Incorporated, South San Francisco, California, USA., Fifer MA; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Maron MS; Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
Corporate Authors: MAPLE-HCM Investigators
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 Mar 03; Vol. 87 (8), pp. 1029-1042. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Aficamten in Obstructive Hypertrophic Cardiomyopathy: A Multidomain, Patient-Level Analysis of the MAPLE-HCM Trial.
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  Data: <searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; Duke University Medical Center, Durham, North Carolina, USA. Electronic address: a.wang@duke.edu.<br /><searchLink fieldCode="AU" term="%22Garcia-Pavia+P%22">Garcia-Pavia P</searchLink>; Hospital Universitario Puerta de Hierro de Majadahonda, IDIPHISA, CIBERCV, Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Masri+A%22">Masri A</searchLink>; Oregon Health Science University, Portland, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Merkely+B%22">Merkely B</searchLink>; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Nassif+ME%22">Nassif ME</searchLink>; University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Peña-Peña+ML%22">Peña-Peña ML</searchLink>; General Hospital of H.U. Virgen Del Rocio, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Barriales-Villa+R%22">Barriales-Villa R</searchLink>; Complexo Hospitalario Universitario A Coruña, INIBIC, CIBERCV-ISCIII, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Bilen+O%22">Bilen O</searchLink>; Emory University Medical Center, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Burroughs+M%22">Burroughs M</searchLink>; Wellstar Center for Cardiovascular Care, Hiram, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Claggett+BL%22">Claggett BL</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Costabel+JP%22">Costabel JP</searchLink>; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22de+Barros+Correia+E%22">de Barros Correia E</searchLink>; Dante Pazzanese Institute of Cardiology, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Dybro+A%22">Dybro A</searchLink>; Aarhus Hospital University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Elliott+P%22">Elliott P</searchLink>; Department of Inherited Cardiovascular Diseases, St Bartholomew's Hospital and Institute of Cardiovascular Science, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hegde+SM%22">Hegde SM</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Kulac+IJ%22">Kulac IJ</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lakdawala+NK%22">Lakdawala NK</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+GD%22">Lewis GD</searchLink>; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Mann+A%22">Mann A</searchLink>; Colorado Springs, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Nair+A%22">Nair A</searchLink>; Texas Heart Institute at Baylor College of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Poulsen+SH%22">Poulsen SH</searchLink>; Aarhus Hospital University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Reant+P%22">Reant P</searchLink>; University Hospital Center of Bordeaux, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Schulze+PC%22">Schulze PC</searchLink>; University Hospital Jena, Friedrich-Schiller-University, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Solomon+SD%22">Solomon SD</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sohn+R%22">Sohn R</searchLink>; Cytokinetics, Incorporated, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Berhane+I%22">Berhane I</searchLink>; Cytokinetics, Incorporated, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Heitner+SB%22">Heitner SB</searchLink>; Cytokinetics, Incorporated, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Jacoby+DL%22">Jacoby DL</searchLink>; Cytokinetics, Incorporated, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Kupfer+S%22">Kupfer S</searchLink>; Cytokinetics, Incorporated, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Malik+FI%22">Malik FI</searchLink>; Cytokinetics, Incorporated, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Wohltman+A%22">Wohltman A</searchLink>; Cytokinetics, Incorporated, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Fifer+MA%22">Fifer MA</searchLink>; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Maron+MS%22">Maron MS</searchLink>; Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
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  Data: <searchLink fieldCode="CA" term="%22MAPLE-HCM+Investigators%22">MAPLE-HCM Investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%228301365%22">Journal of the American College of Cardiology</searchLink> [J Am Coll Cardiol] 2026 Mar 03; Vol. 87 (8), pp. 1029-1042. <i>Date of Electronic Publication: </i>2025 Nov 18.
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