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Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.

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Title: Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.
Authors: Gervais A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France., Marchal A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France., Boucherit S; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France., Abi Haidar A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France., Bizien L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France., Yalcinkaya A; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Türkiye., Sandström E; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Kong XF; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.; McDermott Center for Human Growth and Development, UT Southwestern Medical Center , Dallas, TX, USA., Jacquemin E; Pediatric Hepatology and Liver Transplantation Unit, National Reference Center for Inflammatory Diseases of the Bile Ducts and Autoimmune Hepatitis, FILFOIE, ERN RARE LIVER, Bicêtre Hospital, AP-HP, University Paris-Saclay, Le Kremlin-Bicêtre, France and Inserm UMR_S 1193, University Paris-Saclay , Orsay, France., Bernard O; Pediatric Hepatology and Liver Transplantation Unit, National Reference Center for Inflammatory Diseases of the Bile Ducts and Autoimmune Hepatitis, FILFOIE, ERN RARE LIVER, Bicêtre Hospital, AP-HP, University Paris-Saclay, Le Kremlin-Bicêtre, France and Inserm UMR_S 1193, University Paris-Saclay , Orsay, France., Debray D; Pediatric Liver Unit, National Competence Centre for Inflammatory Diseases of the Bile Ducts and Autoimmune Hepatitis, FILFOIE, ERN RARE LIVER, Assistance Publique-Hôpitaux de Paris (AP-HP)-Necker-Enfants Malades Hospital, University of Paris , Paris, France., Lacaille F; Department of Pediatric Gastroenterology-Nutrition and Pediatric Liver Unit, Necker-Enfants Malades Hospital, University of Paris, Paris, France., Ichai P; Liver Intensive Care Unit, Centre Hépato-Biliaire, AP-HP, Hôpital Paul-Brousse, Université Paris-Saclay, Inserm Research Unit 1193 , Villejuif, France., Arikan C; Koc University School of Medicine, Pediatric Gastroenterology and Hepatology, Organ Transplantation and Research Center, Koc University Research Center for Translational Medicine (KUTTAM) , Istanbul, Turkey., Javouhey E; Pediatric Intensive Care Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon , Lyon, France., Roquelaure B; Multidisciplinary Pediatrics Department, Timone Enfants Hospital, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France., Gottrand F; Pediatric Gastroenterology Hepatology and Nutrition Department, University of Lille, CHU Lille, Lille, France., Trespidi F; Host-Pathogen Group and Neonatal Intensive Care Unit, San Matteo Research Hospital , Pavia, Italy., Codullo V; Division of Rheumatology, San Matteo Research Hospital, Pavia, Italy., Cavagna L; Division of Rheumatology, San Matteo Research Hospital, Pavia, Italy.; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy., Schleinitz N; Internal Medicine Department, La Timone AP-HM, Aix-Marseille Université, Marseille, France., Bousfiha M; Pediatric Infectious Diseases and Clinical Immunology Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University Casablanca , Casablanca, Morocco., Amenzoui N; Pediatric Infectious Diseases and Clinical Immunology Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University Casablanca , Casablanca, Morocco., Bousfiha AA; Pediatric Infectious Diseases and Clinical Immunology Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University Casablanca , Casablanca, Morocco., Jørgensen SE; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Mørk N; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Mogensen TH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP , Paris, France., Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA., Borghesi A; Host-Pathogen Group and Neonatal Intensive Care Unit, San Matteo Research Hospital , Pavia, Italy.; Neonatal Intensive Care Unit, University Hospitals of Geneva , Geneva, Switzerland.; Department of Paediatrics, Gynaecology and Obstetrics, University of Geneva, Geneva, Switzerland.; School of Life Sciences, Swiss Federal Institute of Technology , Lausanne, Switzerland., Rule JA; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Lee WM; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Landegren N; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.; Howard Hughes Medical Institute , New York, NY, USA.; Department of Pediatrics, Necker Hospital for Sick Children, Paris, France., Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.
Source: The Journal of experimental medicine [J Exp Med] 2026 Mar 02; Vol. 223 (3). Date of Electronic Publication: 2025 Dec 05.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.
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  Data: <searchLink fieldCode="AU" term="%22Gervais+A%22">Gervais A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.<br /><searchLink fieldCode="AU" term="%22Marchal+A%22">Marchal A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.<br /><searchLink fieldCode="AU" term="%22Boucherit+S%22">Boucherit S</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.<br /><searchLink fieldCode="AU" term="%22Abi+Haidar+A%22">Abi Haidar A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.<br /><searchLink fieldCode="AU" term="%22Bizien+L%22">Bizien L</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.<br /><searchLink fieldCode="AU" term="%22Yalcinkaya+A%22">Yalcinkaya A</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Türkiye.<br /><searchLink fieldCode="AU" term="%22Sandström+E%22">Sandström E</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Kong+XF%22">Kong XF</searchLink>; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.; McDermott Center for Human Growth and Development, UT Southwestern Medical Center , Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jacquemin+E%22">Jacquemin E</searchLink>; Pediatric Hepatology and Liver Transplantation Unit, National Reference Center for Inflammatory Diseases of the Bile Ducts and Autoimmune Hepatitis, FILFOIE, ERN RARE LIVER, Bicêtre Hospital, AP-HP, University Paris-Saclay, Le Kremlin-Bicêtre, France and Inserm UMR_S 1193, University Paris-Saclay , Orsay, France.<br /><searchLink fieldCode="AU" term="%22Bernard+O%22">Bernard O</searchLink>; Pediatric Hepatology and Liver Transplantation Unit, National Reference Center for Inflammatory Diseases of the Bile Ducts and Autoimmune Hepatitis, FILFOIE, ERN RARE LIVER, Bicêtre Hospital, AP-HP, University Paris-Saclay, Le Kremlin-Bicêtre, France and Inserm UMR_S 1193, University Paris-Saclay , Orsay, France.<br /><searchLink fieldCode="AU" term="%22Debray+D%22">Debray D</searchLink>; Pediatric Liver Unit, National Competence Centre for Inflammatory Diseases of the Bile Ducts and Autoimmune Hepatitis, FILFOIE, ERN RARE LIVER, Assistance Publique-Hôpitaux de Paris (AP-HP)-Necker-Enfants Malades Hospital, University of Paris , Paris, France.<br /><searchLink fieldCode="AU" term="%22Lacaille+F%22">Lacaille F</searchLink>; Department of Pediatric Gastroenterology-Nutrition and Pediatric Liver Unit, Necker-Enfants Malades Hospital, University of Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ichai+P%22">Ichai P</searchLink>; Liver Intensive Care Unit, Centre Hépato-Biliaire, AP-HP, Hôpital Paul-Brousse, Université Paris-Saclay, Inserm Research Unit 1193 , Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Arikan+C%22">Arikan C</searchLink>; Koc University School of Medicine, Pediatric Gastroenterology and Hepatology, Organ Transplantation and Research Center, Koc University Research Center for Translational Medicine (KUTTAM) , Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Javouhey+E%22">Javouhey E</searchLink>; Pediatric Intensive Care Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon , Lyon, France.<br /><searchLink fieldCode="AU" term="%22Roquelaure+B%22">Roquelaure B</searchLink>; Multidisciplinary Pediatrics Department, Timone Enfants Hospital, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.<br /><searchLink fieldCode="AU" term="%22Gottrand+F%22">Gottrand F</searchLink>; Pediatric Gastroenterology Hepatology and Nutrition Department, University of Lille, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Trespidi+F%22">Trespidi F</searchLink>; Host-Pathogen Group and Neonatal Intensive Care Unit, San Matteo Research Hospital , Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Codullo+V%22">Codullo V</searchLink>; Division of Rheumatology, San Matteo Research Hospital, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Cavagna+L%22">Cavagna L</searchLink>; Division of Rheumatology, San Matteo Research Hospital, Pavia, Italy.; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Schleinitz+N%22">Schleinitz N</searchLink>; Internal Medicine Department, La Timone AP-HM, Aix-Marseille Université, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bousfiha+M%22">Bousfiha M</searchLink>; Pediatric Infectious Diseases and Clinical Immunology Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University Casablanca , Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Amenzoui+N%22">Amenzoui N</searchLink>; Pediatric Infectious Diseases and Clinical Immunology Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University Casablanca , Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Bousfiha+AA%22">Bousfiha AA</searchLink>; Pediatric Infectious Diseases and Clinical Immunology Department, Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco.; Laboratory of Clinical Immunology, Infection and Autoimmunity (LICIA), Faculty of Medicine and Pharmacy, Hassan II University Casablanca , Casablanca, Morocco.<br /><searchLink fieldCode="AU" term="%22Jørgensen+SE%22">Jørgensen SE</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Mørk+N%22">Mørk N</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Mogensen+TH%22">Mogensen TH</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Bastard+P%22">Bastard P</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP , Paris, France.<br /><searchLink fieldCode="AU" term="%22Puel+A%22">Puel A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Borghesi+A%22">Borghesi A</searchLink>; Host-Pathogen Group and Neonatal Intensive Care Unit, San Matteo Research Hospital , Pavia, Italy.; Neonatal Intensive Care Unit, University Hospitals of Geneva , Geneva, Switzerland.; Department of Paediatrics, Gynaecology and Obstetrics, University of Geneva, Geneva, Switzerland.; School of Life Sciences, Swiss Federal Institute of Technology , Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rule+JA%22">Rule JA</searchLink>; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WM%22">Lee WM</searchLink>; Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Landegren+N%22">Landegren N</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Cobat+A%22">Cobat A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.; Howard Hughes Medical Institute , New York, NY, USA.; Department of Pediatrics, Necker Hospital for Sick Children, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jouanguy+E%22">Jouanguy E</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children , Paris, France.; Paris Cité University, Imagine Institute , Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.
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              Value: 3
          Titles:
            – TitleFull: The Journal of experimental medicine
              Type: main
ResultId 1