Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency.

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Title: Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency.
Authors: Verhaegen M; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Croonenborghs M; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Sorout N; Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany., Sartori A; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Provinciael B; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Meyen E; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Stroobants J; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Hermans R; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Jacquemyn M; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Daelemans D; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Rosales-Rosas AL; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Delang L; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Maes P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Hartmann E; Centre for Structural and Cell Biology in Medicine, Institute of Biology, University of Lübeck, 23562 Lübeck, Germany., Helms V; Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany., Vermeire K; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address: kurt.vermeire@kuleuven.be.
Source: Cell reports [Cell Rep] 2025 Dec 23; Vol. 44 (12), pp. 116642. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2211-1247
DOI:10.1016/j.celrep.2025.116642