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Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency.

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Title: Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency.
Authors: Verhaegen M; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Croonenborghs M; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Sorout N; Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany., Sartori A; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Provinciael B; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Meyen E; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Stroobants J; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Hermans R; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Jacquemyn M; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Daelemans D; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Rosales-Rosas AL; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Delang L; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Maes P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Hartmann E; Centre for Structural and Cell Biology in Medicine, Institute of Biology, University of Lübeck, 23562 Lübeck, Germany., Helms V; Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany., Vermeire K; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address: kurt.vermeire@kuleuven.be.
Source: Cell reports [Cell Rep] 2025 Dec 23; Vol. 44 (12), pp. 116642. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency.
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  Data: <searchLink fieldCode="AU" term="%22Verhaegen+M%22">Verhaegen M</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Croonenborghs+M%22">Croonenborghs M</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sorout+N%22">Sorout N</searchLink>; Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany.<br /><searchLink fieldCode="AU" term="%22Sartori+A%22">Sartori A</searchLink>; Department of Food and Drug, University of Parma, 43124 Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Provinciael+B%22">Provinciael B</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Meyen+E%22">Meyen E</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Stroobants+J%22">Stroobants J</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Hermans+R%22">Hermans R</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jacquemyn+M%22">Jacquemyn M</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Daelemans+D%22">Daelemans D</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Rosales-Rosas+AL%22">Rosales-Rosas AL</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Delang+L%22">Delang L</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Maes+P%22">Maes P</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Hartmann+E%22">Hartmann E</searchLink>; Centre for Structural and Cell Biology in Medicine, Institute of Biology, University of Lübeck, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Helms+V%22">Helms V</searchLink>; Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Saarland, Germany.<br /><searchLink fieldCode="AU" term="%22Vermeire+K%22">Vermeire K</searchLink>; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address: kurt.vermeire@kuleuven.be.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2025 Dec 23; Vol. 44 (12), pp. 116642. <i>Date of Electronic Publication: </i>2025 Dec 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101573691 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2211-1247 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Rep <i>Subsets: </i>MEDLINE
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