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A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma.

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Title: A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma.
Authors: Rade M; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany., Fandrei D; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Kreuz M; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany., Seiffert S; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany., Grahnert A; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany., Friedrich M; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany., Wiemers T; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Born P; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Fischer L; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Weidner H; Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Hofbauer LC; Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Baber R; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; Leipzig Medical Biobank, University Leipzig, Leipzig, Germany., Wang SY; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Bach E; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Hoffmann S; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Scolnick J; Singleron Biotechnologies, Singapore, Singapore., Friedrich M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Keramati F; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Brazda P; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Sebestyen Z; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kuball J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Alb M; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany., Scheller L; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany., Hudecek M; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany., Einsele H; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany., Metzeler KH; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Herling M; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Herling CD; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Jentzsch M; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Franke GN; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Boldt A; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany., Köhl U; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Platzbecker U; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Vucinic V; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany., Reiche K; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden, Leipzig, Germany., Merz M; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; Myeloma and Cellular Therapy Services, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: merzm@mskcc.org.
Source: Cancer cell [Cancer Cell] 2026 Mar 09; Vol. 44 (3), pp. 586-603.e9. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Rade+M%22">Rade M</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Fandrei+D%22">Fandrei D</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Kreuz+M%22">Kreuz M</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Seiffert+S%22">Seiffert S</searchLink>; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Grahnert+A%22">Grahnert A</searchLink>; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Friedrich+M%22">Friedrich M</searchLink>; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Wiemers+T%22">Wiemers T</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Born+P%22">Born P</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+L%22">Fischer L</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Weidner+H%22">Weidner H</searchLink>; Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Hofbauer+LC%22">Hofbauer LC</searchLink>; Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Baber+R%22">Baber R</searchLink>; Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; Leipzig Medical Biobank, University Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+SY%22">Wang SY</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Bach+E%22">Bach E</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+S%22">Hoffmann S</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Scolnick+J%22">Scolnick J</searchLink>; Singleron Biotechnologies, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Friedrich+M%22">Friedrich M</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Keramati+F%22">Keramati F</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Brazda+P%22">Brazda P</searchLink>; 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Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hudecek+M%22">Hudecek M</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Einsele+H%22">Einsele H</searchLink>; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Metzeler+KH%22">Metzeler KH</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Herling+M%22">Herling M</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; 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Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Köhl+U%22">Köhl U</searchLink>; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Platzbecker+U%22">Platzbecker U</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Vucinic+V%22">Vucinic V</searchLink>; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; 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