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Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines.

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Title: Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines.
Authors: Li Y; National Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun, China.; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China., Zhou Y; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China., Bortolus MR; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada., Zhang X; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China., Wang Z; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China., Liu D; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China., Le H; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada., Esezobor OZ; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Ni J; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China., Zhang Q; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China., Vasdev N; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada., Cheng GJ; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China. chengguijuan@cuhk.edu.cn., Zheng C; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. chao.zheng@camh.ca.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada. chao.zheng@camh.ca., Fu J; National Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun, China. fujk109@nenu.edu.cn.; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China. fujk109@nenu.edu.cn.
Source: Nature communications [Nat Commun] 2025 Dec 05; Vol. 16 (1), pp. 10917. Date of Electronic Publication: 2025 Dec 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; National Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun, China.; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Bortolus+MR%22">Bortolus MR</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Le+H%22">Le H</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Esezobor+OZ%22">Esezobor OZ</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ni+J%22">Ni J</searchLink>; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Vasdev+N%22">Vasdev N</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cheng+GJ%22">Cheng GJ</searchLink>; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China. chengguijuan@cuhk.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. chao.zheng@camh.ca.; Department of Chemistry, Pharmacology and Toxicology, and/or Psychiatry, University of Toronto, Toronto, ON, Canada. chao.zheng@camh.ca.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; National Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun, China. fujk109@nenu.edu.cn.; Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Northeast Normal University, Changchun, China. fujk109@nenu.edu.cn.
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