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IGF2BP3 recognizes m6A to regulate histone-to-protamine replacement during mouse sperm development.

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Title: IGF2BP3 recognizes m6A to regulate histone-to-protamine replacement during mouse sperm development.
Authors: Wang D; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Huang Z; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Zhou Y; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Chen P; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Chang G; Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, 518060, Shenzhen, P. R. China., Ke L; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Jing C; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Yang H; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Zhao J; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Ren S; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Zheng Y; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Chen Y; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China., Xiang Y; State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, P. R. China., Liu J; State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, P. R. China., Wang M; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P. R. China. wangmei94@smu.edu.cn.; Department of Neonatology, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, P. R. China. wangmei94@smu.edu.cn.
Source: The EMBO journal [EMBO J] 2026 Jan; Vol. 45 (2), pp. 504-536. Date of Electronic Publication: 2025 Dec 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00659-y