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Dibifree, a dietary phytomix, improves glycemic control and adiposity via modulation of the gut-pancreas-adipose-immune axis in type 2 diabetes.

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Title: Dibifree, a dietary phytomix, improves glycemic control and adiposity via modulation of the gut-pancreas-adipose-immune axis in type 2 diabetes.
Authors: Huang TY; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Dai NT; Division of Plastic and Reconstructive Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114202, Taiwan., Liao HJ; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Doan LH; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Cheng TS; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Graduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan., Hsieh WY; Biomedical Industry Ph.D. Program, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Lin IH; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan., Huang YT; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Biomedical Industry Ph.D. Program, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Liaw CC; Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan; Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Liu HS; Medical Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; M. Sc. Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Cheng WM; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Division of Urology, Department of Surgery, Taipei City Hospital, Zhongxiao Branch, Taipei 11556, Taiwan., Su CL; Graduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan., Yang CW; Department of Urology, Cheng-Hsin General Hospital, Taipei 112401, Taiwan; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan., Lai JM; Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City 24205, Taiwan., Tuan MN; Global Preventive Medicine Biotech Co., Ltd., New Taipei City 22102, Taiwan; Geninova Biotech Co., Ltd., New Taipei City 22102, Taiwan., Liu HK; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan; Ph.D. Program in the Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei 11031, Taiwan; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan. Electronic address: hk.liu@nricm.edu.tw., Huang CF; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Chong Hin Loon Memorial Cancer and Biotherapy Research Center, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Electronic address: cyhuang5@nycu.edu.tw.
Source: Food research international (Ottawa, Ont.) [Food Res Int] 2026 Jan; Vol. 223 (Pt 1), pp. 117820. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dibifree, a dietary phytomix, improves glycemic control and adiposity via modulation of the gut-pancreas-adipose-immune axis in type 2 diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Huang+TY%22">Huang TY</searchLink>; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Dai+NT%22">Dai NT</searchLink>; Division of Plastic and Reconstructive Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114202, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+HJ%22">Liao HJ</searchLink>; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Doan+LH%22">Doan LH</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+TS%22">Cheng TS</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Graduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+WY%22">Hsieh WY</searchLink>; Biomedical Industry Ph.D. Program, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+IH%22">Lin IH</searchLink>; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YT%22">Huang YT</searchLink>; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Biomedical Industry Ph.D. Program, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liaw+CC%22">Liaw CC</searchLink>; Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan; Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+HS%22">Liu HS</searchLink>; Medical Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; M. 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Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+WM%22">Cheng WM</searchLink>; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Division of Urology, Department of Surgery, Taipei City Hospital, Zhongxiao Branch, Taipei 11556, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+CL%22">Su CL</searchLink>; Graduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+CW%22">Yang CW</searchLink>; Department of Urology, Cheng-Hsin General Hospital, Taipei 112401, Taiwan; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+JM%22">Lai JM</searchLink>; Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City 24205, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tuan+MN%22">Tuan MN</searchLink>; Global Preventive Medicine Biotech Co., Ltd., New Taipei City 22102, Taiwan; Geninova Biotech Co., Ltd., New Taipei City 22102, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+HK%22">Liu HK</searchLink>; Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan; Ph.D. Program in the Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei 11031, Taiwan; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan. Electronic address: hk.liu@nricm.edu.tw.<br /><searchLink fieldCode="AU" term="%22Huang+CF%22">Huang CF</searchLink>; Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Chong Hin Loon Memorial Cancer and Biotherapy Research Center, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan. Electronic address: cyhuang5@nycu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%229210143%22">Food research international (Ottawa, Ont.)</searchLink> [Food Res Int] 2026 Jan; Vol. 223 (Pt 1), pp. 117820. <i>Date of Electronic Publication: </i>2025 Nov 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Published+on+behalf+of+the+Canadian+Institute+of+Food+Science+and+Technology+by+Elsevier+Applied+Science%22">Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science </searchLink><i>Country of Publication: </i>Canada <i>NLM ID: </i>9210143 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-7145 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209639969%22">09639969 </searchLink><i>NLM ISO Abbreviation: </i>Food Res Int <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.foodres.2025.117820
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      – Code: eng
        Text: English
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        StartPage: 117820
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              Text: 2026 Jan
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