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A Lung-Immune Dual-Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses.

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Title: A Lung-Immune Dual-Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses.
Authors: Cheng C; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China., Sun J; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.; School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China., Lu C; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China., Yu Q; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China., He Y; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China., Wu B; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China., Ren D; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China., Ding S; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China., Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.; School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, 510005, China.; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China., Li Y; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.; Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, Nanjing University, Nanjing, 210093, China.; Wuxi Xishan NJU Institute of Applied Biotechnology, Wuxi, 214000, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Mar; Vol. 13 (16), pp. e12097. Date of Electronic Publication: 2025 Dec 07.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Lung-Immune Dual-Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+C%22">Cheng C</searchLink>; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.; School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.<br /><searchLink fieldCode="AU" term="%22Lu+C%22">Lu C</searchLink>; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.<br /><searchLink fieldCode="AU" term="%22Ren+D%22">Ren D</searchLink>; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Ding+S%22">Ding S</searchLink>; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.; School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, 510005, China.; Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210093, China.; Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, Nanjing University, Nanjing, 210093, China.; Wuxi Xishan NJU Institute of Applied Biotechnology, Wuxi, 214000, China.
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        Value: 10.1002/advs.202512097
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      – TitleFull: A Lung-Immune Dual-Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses.
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              Text: 2026 Mar
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