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Design, synthesis, and mechanistic evaluation of alepterolic acid derivatives incorporating indole and piperazine moieties as anticancer agents targeting breast cancer.

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Title: Design, synthesis, and mechanistic evaluation of alepterolic acid derivatives incorporating indole and piperazine moieties as anticancer agents targeting breast cancer.
Authors: Ma L; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China., Sun Y; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China., Zhang B; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China., Tong Z; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China., Jia Y; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China., Wang P; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China., Ou B; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China., Cao J; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China. cao101@shnu.edu.cn., Huang G; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China. guozheng.huang@ahut.edu.cn.
Source: Molecular diversity [Mol Divers] 2025 Dec 07. Date of Electronic Publication: 2025 Dec 07.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis, and mechanistic evaluation of alepterolic acid derivatives incorporating indole and piperazine moieties as anticancer agents targeting breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Tong+Z%22">Tong Z</searchLink>; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Jia+Y%22">Jia Y</searchLink>; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ou+B%22">Ou B</searchLink>; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; College of Life Sciences, Shanghai Normal University, Shanghai, 201418, People's Republic of China. cao101@shnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Huang+G%22">Huang G</searchLink>; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, China. guozheng.huang@ahut.edu.cn.
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        Value: 10.1007/s11030-025-11406-0
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        Text: English
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            – D: 07
              M: 12
              Text: 2025 Dec 07
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              Y: 2025
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