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Safety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis.

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Title: Safety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis.
Authors: Vrotniakaite-Bajerciene K; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Mallick R; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Takada T; Department of General Medicine, Shirakawa Satellite for Teaching and Research, Fukushima Medical University, Fukushima, Japan., Kraaijpoel N; Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., van Smeden M; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Moons KGM; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kline JA; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Huisman MV; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands., Martens E; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: https://x.com/ESLMartens., Righini M; Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland., van Es N; Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Klok FA; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands., Büller HR; Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Perrier A; Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland., de Wit K; Department of Emergency Medicine and Medicine, Queen's University Hospital, Kingston, Ontario, Canada., Wells PS; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Galipienzo J; Department of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Madrid, Spain., Ghanima W; Department of Hematology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway., Roy PM; Emergency Department, Angers University Hospital, Angers, France., Carrier M; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: https://x.com/MarcCarrier1., Geersing GJ; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Le Gal G; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: glegal@toh.ca.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2026 Mar; Vol. 24 (3), pp. 971-984. Date of Electronic Publication: 2025 Dec 05.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Vrotniakaite-Bajerciene+K%22">Vrotniakaite-Bajerciene K</searchLink>; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mallick+R%22">Mallick R</searchLink>; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Takada+T%22">Takada T</searchLink>; Department of General Medicine, Shirakawa Satellite for Teaching and Research, Fukushima Medical University, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Kraaijpoel+N%22">Kraaijpoel N</searchLink>; Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Smeden+M%22">van Smeden M</searchLink>; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Moons+KGM%22">Moons KGM</searchLink>; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kline+JA%22">Kline JA</searchLink>; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Huisman+MV%22">Huisman MV</searchLink>; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Martens+E%22">Martens E</searchLink>; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: https://x.com/ESLMartens.<br /><searchLink fieldCode="AU" term="%22Righini+M%22">Righini M</searchLink>; Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22van+Es+N%22">van Es N</searchLink>; Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Klok+FA%22">Klok FA</searchLink>; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Büller+HR%22">Büller HR</searchLink>; Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Perrier+A%22">Perrier A</searchLink>; Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22de+Wit+K%22">de Wit K</searchLink>; Department of Emergency Medicine and Medicine, Queen's University Hospital, Kingston, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wells+PS%22">Wells PS</searchLink>; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Galipienzo+J%22">Galipienzo J</searchLink>; Department of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ghanima+W%22">Ghanima W</searchLink>; Department of Hematology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Roy+PM%22">Roy PM</searchLink>; Emergency Department, Angers University Hospital, Angers, France.<br /><searchLink fieldCode="AU" term="%22Carrier+M%22">Carrier M</searchLink>; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: https://x.com/MarcCarrier1.<br /><searchLink fieldCode="AU" term="%22Geersing+GJ%22">Geersing GJ</searchLink>; Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Le+Gal+G%22">Le Gal G</searchLink>; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: glegal@toh.ca.
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  Data: <searchLink fieldCode="JN" term="%22101170508%22">Journal of thrombosis and haemostasis : JTH</searchLink> [J Thromb Haemost] 2026 Mar; Vol. 24 (3), pp. 971-984. <i>Date of Electronic Publication: </i>2025 Dec 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170508 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7836 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215387836%22">15387836 </searchLink><i>NLM ISO Abbreviation: </i>J Thromb Haemost <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jtha.2025.10.035
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              Text: 2026 Mar
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