The Effect of Local Infiltration of Dexmedetomidine as an Adjuvant on Breakthrough Pain During Epidural Labor Analgesia: A Randomized Controlled Trial.

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Title: The Effect of Local Infiltration of Dexmedetomidine as an Adjuvant on Breakthrough Pain During Epidural Labor Analgesia: A Randomized Controlled Trial.
Authors: Liu D; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Wang X; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Wu XX; Department of Anesthesiology, the Maternal and Child Health Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China., Ouyang RN; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Niu JY; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Tao QY; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Wang YH; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Wang J; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Zhu H; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China., Zhang F; Department of Birthing Center, the Maternal and Child Health Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China., Zhu HJ; Department of Anesthesiology, the Maternal and Child Health Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China., Yu JM; Department of Anesthesiology, the Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2025 Dec 02; Vol. 19, pp. 10621-10631. Date of Electronic Publication: 2025 Dec 02 (Print Publication: 2025).
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1177-8881
DOI:10.2147/DDDT.S553879