Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial. - Haji Sadeghi M; Cohen J; Williams B; Wilkinson A; Sumpter S; Simms L; Huang C; Pugh K; Heath C; Sangiorgi L; Gurioli F; Gnoli M; et al. (BMJ open, 2025)