Multicentre controlled open randomised clinical trial to assess efficacy and safety of an anti-tuberculosis drug combination based on optimised-dose rifampicin, optimised-dose moxifloxacin and optimised-dose linezolid for TB: the RML-TB trial protocol.
Saved in:
| Title: | Multicentre controlled open randomised clinical trial to assess efficacy and safety of an anti-tuberculosis drug combination based on optimised-dose rifampicin, optimised-dose moxifloxacin and optimised-dose linezolid for TB: the RML-TB trial protocol. |
|---|---|
| Authors: | Diab Casares L; Clinical Microbiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain.; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain., Espinosa Pereiro J; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Tórtola Fernández MT; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.; Microbiology Department, Autonomous University of Barcelona, Medicine Department, Campus Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain., Casas García X; Respiratory Department, Serveis Clinics SAU, Barcelona, Cataluña, Spain.; Respiratory Infections Working Group of the Catalan Society of Respiratory Medicine (SOCAP), Cataluña, Cataluña., Millet JP; Epidemiology, Public Health Agency of Catalonia, Barcelona, Cataluña, Spain.; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain., Pomar Solchaga V; Infectious Diseases Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Cataluña, Spain., Navas Elorza E; Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, Spain., Troya García J; Department of Internal Medicine, Hospital Universitario Infanta Leonor, Madrid, Spain., Díaz de Santiago A; Department of Internal Medicine, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Luque Márquez R; Infectious Diseases Department, Hospital Universitario Virgen del Rocío, Sevilla, Andalucía, Spain., Medina Gallardo JF; Medical-Surgical Unit for Respiratory Diseases (UMQER), Hospital Universitario Virgen del Rocío, Sevilla, Andalucía, Spain.; Integrated Research Program on Tuberculosis and Nontuberculous Mycobacteria (PII-TB&MNT), Spanish Society of Respiratory Medicine and Thoracic Surgery (SEPAR), Spain., González Galán V; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Clinical Unit of Infectious Diseases, Microbiology and Clinical Parasitology (UCEIMP), Hospital Universitario Virgen del Rocío, Sevilla, Spain.; Seville Institute of Biomedicine, Sevilla, Andalucía, Spain., Montero Alonso M; Infectious Diseases Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain., Gil Brusola A; Microbiology Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain., Rabuñal Rey R; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Department of Internal Medicine, Hospital Universitario Lucus Augusti, Lugo, Spain., Anibarro García L; Tuberculosis Unit, Infectious Diseases, Internal Medicine Department, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Galicia, Spain.; Immunology Research Group, Research Institute, Sanitaria Galicia Sur, Santiago de Compostela, Spain., Sanz Herrero F; Respiratory Department, Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain., Guna Serrano R; Clinical Microbiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain.; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Clinical Microbiology Department, Faculty of Medicine, University of Valencia, Valencia, Spain., Garrigó Fullola M; Clinical Microbiology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Sant Pau Biomedical Research Institute, Barcelona, Cataluña, Spain.; Department of Genetics and Microbiology, Autonomous University of Barcelona, Barcelona, Cataluña, Spain., Tato Díez M; Clinical Microbiology Department, Hospital Universitario Ramon y Cajal, Madrid, Madrid, Spain., Talavan Zanón T; Clinical Microbiology Department, Hospital Universitario Infanta Leonor, Madrid, Spain., Portero MF; Clinical Microbiology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Alonso García P; Clinical Microbiology Department, Hospital Universitario Lucus Augusti, Lugo, Galicia, Spain., Saez López AM; Clinical Microbiology Department, Hospital Provincial de Pontevedra, Pontevedra, Galicia, Spain., Aznar ML; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Martínez Campreciós J; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Saborit N; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain., Sánchez Montalvá A; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain adrian.sanchez.montalva@gmail.com.; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. |
| Source: | BMJ open respiratory research [BMJ Open Respir Res] 2025 Dec 07; Vol. 12 (1). Date of Electronic Publication: 2025 Dec 07. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: BMJ Publishing Group Ltd & British Thoracic Society Country of Publication: England NLM ID: 101638061 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4439 (Electronic) Linking ISSN: 20524439 NLM ISO Abbreviation: BMJ Open Respir Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41360613 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Multicentre controlled open randomised clinical trial to assess efficacy and safety of an anti-tuberculosis drug combination based on optimised-dose rifampicin, optimised-dose moxifloxacin and optimised-dose linezolid for TB: the RML-TB trial protocol. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Diab+Casares+L%22">Diab Casares L</searchLink>; Clinical Microbiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain.; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.<br /><searchLink fieldCode="AU" term="%22Espinosa+Pereiro+J%22">Espinosa Pereiro J</searchLink>; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tórtola+Fernández+MT%22">Tórtola Fernández MT</searchLink>; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.; Microbiology Department, Autonomous University of Barcelona, Medicine Department, Campus Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.<br /><searchLink fieldCode="AU" term="%22Casas+García+X%22">Casas García X</searchLink>; Respiratory Department, Serveis Clinics SAU, Barcelona, Cataluña, Spain.; Respiratory Infections Working Group of the Catalan Society of Respiratory Medicine (SOCAP), Cataluña, Cataluña.<br /><searchLink fieldCode="AU" term="%22Millet+JP%22">Millet JP</searchLink>; Epidemiology, Public Health Agency of Catalonia, Barcelona, Cataluña, Spain.; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pomar+Solchaga+V%22">Pomar Solchaga V</searchLink>; Infectious Diseases Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Cataluña, Spain.<br /><searchLink fieldCode="AU" term="%22Navas+Elorza+E%22">Navas Elorza E</searchLink>; Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Troya+García+J%22">Troya García J</searchLink>; Department of Internal Medicine, Hospital Universitario Infanta Leonor, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Díaz+de+Santiago+A%22">Díaz de Santiago A</searchLink>; Department of Internal Medicine, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Luque+Márquez+R%22">Luque Márquez R</searchLink>; Infectious Diseases Department, Hospital Universitario Virgen del Rocío, Sevilla, Andalucía, Spain.<br /><searchLink fieldCode="AU" term="%22Medina+Gallardo+JF%22">Medina Gallardo JF</searchLink>; Medical-Surgical Unit for Respiratory Diseases (UMQER), Hospital Universitario Virgen del Rocío, Sevilla, Andalucía, Spain.; Integrated Research Program on Tuberculosis and Nontuberculous Mycobacteria (PII-TB&MNT), Spanish Society of Respiratory Medicine and Thoracic Surgery (SEPAR), Spain.<br /><searchLink fieldCode="AU" term="%22González+Galán+V%22">González Galán V</searchLink>; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Clinical Unit of Infectious Diseases, Microbiology and Clinical Parasitology (UCEIMP), Hospital Universitario Virgen del Rocío, Sevilla, Spain.; Seville Institute of Biomedicine, Sevilla, Andalucía, Spain.<br /><searchLink fieldCode="AU" term="%22Montero+Alonso+M%22">Montero Alonso M</searchLink>; Infectious Diseases Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Gil+Brusola+A%22">Gil Brusola A</searchLink>; Microbiology Department, Hospital Universitario y Politecnico La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Rabuñal+Rey+R%22">Rabuñal Rey R</searchLink>; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Department of Internal Medicine, Hospital Universitario Lucus Augusti, Lugo, Spain.<br /><searchLink fieldCode="AU" term="%22Anibarro+García+L%22">Anibarro García L</searchLink>; Tuberculosis Unit, Infectious Diseases, Internal Medicine Department, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Galicia, Spain.; Immunology Research Group, Research Institute, Sanitaria Galicia Sur, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+Herrero+F%22">Sanz Herrero F</searchLink>; Respiratory Department, Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain.<br /><searchLink fieldCode="AU" term="%22Guna+Serrano+R%22">Guna Serrano R</searchLink>; Clinical Microbiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Comunidad Valenciana, Spain.; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Clinical Microbiology Department, Faculty of Medicine, University of Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Garrigó+Fullola+M%22">Garrigó Fullola M</searchLink>; Clinical Microbiology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Sant Pau Biomedical Research Institute, Barcelona, Cataluña, Spain.; Department of Genetics and Microbiology, Autonomous University of Barcelona, Barcelona, Cataluña, Spain.<br /><searchLink fieldCode="AU" term="%22Tato+Díez+M%22">Tato Díez M</searchLink>; Clinical Microbiology Department, Hospital Universitario Ramon y Cajal, Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Talavan+Zanón+T%22">Talavan Zanón T</searchLink>; Clinical Microbiology Department, Hospital Universitario Infanta Leonor, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Portero+MF%22">Portero MF</searchLink>; Clinical Microbiology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso+García+P%22">Alonso García P</searchLink>; Clinical Microbiology Department, Hospital Universitario Lucus Augusti, Lugo, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Saez+López+AM%22">Saez López AM</searchLink>; Clinical Microbiology Department, Hospital Provincial de Pontevedra, Pontevedra, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Aznar+ML%22">Aznar ML</searchLink>; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain.; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez+Campreciós+J%22">Martínez Campreciós J</searchLink>; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Saborit+N%22">Saborit N</searchLink>; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez+Montalvá+A%22">Sánchez Montalvá A</searchLink>; Mycobacteria Study Group, Spanish Society of Infectious Diseases and Clinical Microbiology (GEIM-SEIMC), Spain, Spain adrian.sanchez.montalva@gmail.com.; Infectious Diseases Department, Hospital Universitario Vall d'Hebron, Barcelona, Cataluña, Spain.; Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101638061%22">BMJ open respiratory research</searchLink> [BMJ Open Respir Res] 2025 Dec 07; Vol. 12 (1). <i>Date of Electronic Publication: </i>2025 Dec 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd+%26+British+Thoracic+Society%22">BMJ Publishing Group Ltd & British Thoracic Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101638061 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2052-4439 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220524439%22">20524439 </searchLink><i>NLM ISO Abbreviation: </i>BMJ Open Respir Res <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41360613 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1136/bmjresp-2024-002475 Languages: – Code: eng Text: English Titles: – TitleFull: Multicentre controlled open randomised clinical trial to assess efficacy and safety of an anti-tuberculosis drug combination based on optimised-dose rifampicin, optimised-dose moxifloxacin and optimised-dose linezolid for TB: the RML-TB trial protocol. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Diab Casares L – PersonEntity: Name: NameFull: Espinosa Pereiro J – PersonEntity: Name: NameFull: Tórtola Fernández MT – PersonEntity: Name: NameFull: Casas García X – PersonEntity: Name: NameFull: Millet JP – PersonEntity: Name: NameFull: Pomar Solchaga V – PersonEntity: Name: NameFull: Navas Elorza E – PersonEntity: Name: NameFull: Troya García J – PersonEntity: Name: NameFull: Díaz de Santiago A – PersonEntity: Name: NameFull: Luque Márquez R – PersonEntity: Name: NameFull: Medina Gallardo JF – PersonEntity: Name: NameFull: González Galán V – PersonEntity: Name: NameFull: Montero Alonso M – PersonEntity: Name: NameFull: Gil Brusola A – PersonEntity: Name: NameFull: Rabuñal Rey R – PersonEntity: Name: NameFull: Anibarro García L – PersonEntity: Name: NameFull: Sanz Herrero F – PersonEntity: Name: NameFull: Guna Serrano R – PersonEntity: Name: NameFull: Garrigó Fullola M – PersonEntity: Name: NameFull: Tato Díez M – PersonEntity: Name: NameFull: Talavan Zanón T – PersonEntity: Name: NameFull: Portero MF – PersonEntity: Name: NameFull: Alonso García P – PersonEntity: Name: NameFull: Saez López AM – PersonEntity: Name: NameFull: Aznar ML – PersonEntity: Name: NameFull: Martínez Campreciós J – PersonEntity: Name: NameFull: Saborit N – PersonEntity: Name: NameFull: Sánchez Montalvá A IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 12 Text: 2025 Dec 07 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2052-4439 Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: BMJ open respiratory research Type: main |
| ResultId | 1 |
