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CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer.

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Title: CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer.
Authors: Napolitano F; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Wang Y; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA., Sudhan DR; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Gonzalez-Ericsson PI; Departments of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA., Formisano L; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Unni N; Department of Medical Oncology., Shakeel S; Department of Medical Oncology., Zhu JZ; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and., Ahuja K; Lyda Hill Department of Bioinformatics, UTSW Medical Center, Dallas, Texas, USA., Guo L; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and., Chica-Parrado MR; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Matsunaga Y; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Luna P; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Lin CA; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Uemoto Y; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Lee KM; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.; Department of Life Sciences, College of Natural Science, Hanyang University, Seoul, South Korea., Ma H; Knight Cancer Institute, and., Evans NJ; Knight Cancer Institute, and.; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA., Servetto A; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Mendiratta S; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Barnes SD; Lyda Hill Department of Bioinformatics, UTSW Medical Center, Dallas, Texas, USA., Bianco R; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Fang YV; Department of Pathology, UTSW Medical Center, Dallas, Texas, USA., Xu L; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and., Lee J; Lyda Hill Department of Bioinformatics, UTSW Medical Center, Dallas, Texas, USA., Wang T; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and., Balko JM; Departments of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt-Ingram Cancer Center, VUMC, Nashville, Tennessee, USA., Mills GB; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA., Labrie M; Department of Immunology and Cell Biology, Faculty of Medicine and Health Science, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Institut de Recherche sur le Cancer de l'Université de Sherbrooke, Sherbrooke, Canada., Hanker AB; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA., Arteaga CL; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Dec 09; Vol. 136 (3). Date of Electronic Publication: 2025 Dec 09 (Print Publication: 2026).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Napolitano+F%22">Napolitano F</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Sudhan+DR%22">Sudhan DR</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Ericsson+PI%22">Gonzalez-Ericsson PI</searchLink>; Departments of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Formisano+L%22">Formisano L</searchLink>; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Unni+N%22">Unni N</searchLink>; Department of Medical Oncology.<br /><searchLink fieldCode="AU" term="%22Shakeel+S%22">Shakeel S</searchLink>; Department of Medical Oncology.<br /><searchLink fieldCode="AU" term="%22Zhu+JZ%22">Zhu JZ</searchLink>; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and.<br /><searchLink fieldCode="AU" term="%22Ahuja+K%22">Ahuja K</searchLink>; Lyda Hill Department of Bioinformatics, UTSW Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Guo+L%22">Guo L</searchLink>; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and.<br /><searchLink fieldCode="AU" term="%22Chica-Parrado+MR%22">Chica-Parrado MR</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Matsunaga+Y%22">Matsunaga Y</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Luna+P%22">Luna P</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Lin+CA%22">Lin CA</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Uemoto+Y%22">Uemoto Y</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Lee+KM%22">Lee KM</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.; Department of Life Sciences, College of Natural Science, Hanyang University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Knight Cancer Institute, and.<br /><searchLink fieldCode="AU" term="%22Evans+NJ%22">Evans NJ</searchLink>; Knight Cancer Institute, and.; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Servetto+A%22">Servetto A</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Mendiratta+S%22">Mendiratta S</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Barnes+SD%22">Barnes SD</searchLink>; Lyda Hill Department of Bioinformatics, UTSW Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Bianco+R%22">Bianco R</searchLink>; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Fang+YV%22">Fang YV</searchLink>; Department of Pathology, UTSW Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Lyda Hill Department of Bioinformatics, UTSW Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, and.<br /><searchLink fieldCode="AU" term="%22Balko+JM%22">Balko JM</searchLink>; Departments of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt-Ingram Cancer Center, VUMC, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Mills+GB%22">Mills GB</searchLink>; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Labrie+M%22">Labrie M</searchLink>; Department of Immunology and Cell Biology, Faculty of Medicine and Health Science, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Institut de Recherche sur le Cancer de l'Université de Sherbrooke, Sherbrooke, Canada.<br /><searchLink fieldCode="AU" term="%22Hanker+AB%22">Hanker AB</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Arteaga+CL%22">Arteaga CL</searchLink>; UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Dec 09; Vol. 136 (3). <i>Date of Electronic Publication: </i>2025 Dec 09 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
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