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Therapeutic Targeting of Epithelial-Mesenchymal Cellular Plasticity in Pancreatic Cancer.

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Title: Therapeutic Targeting of Epithelial-Mesenchymal Cellular Plasticity in Pancreatic Cancer.
Authors: Lin EW; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Pathak P; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., O'Shea A; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Awasthi B; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Phillips IE; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Kocher JR; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Song Y; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Raabe MJ; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Xu KH; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Patel BK; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Lester N; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Bae JW; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Zhang ML; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Nieman LT; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Blazkowsky LS; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Walsh EP; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Parikh AR; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Hansen A; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Caufield J; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Newbert G; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Asombang AW; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Casey B; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Cohen J; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Jacobson BC; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Krishnan K; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Uppot R; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Weissleder R; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Horick NK; Biostatistics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Hwang WL; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Harisinghani MG; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ting DT; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Weekes CD; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Mar 02; Vol. 32 (5), pp. 869-882.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lin+EW%22">Lin EW</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Pathak+P%22">Pathak P</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22O'Shea+A%22">O'Shea A</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Awasthi+B%22">Awasthi B</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Phillips+IE%22">Phillips IE</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kocher+JR%22">Kocher JR</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Raabe+MJ%22">Raabe MJ</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Xu+KH%22">Xu KH</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Patel+BK%22">Patel BK</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lester+N%22">Lester N</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; 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Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Parikh+AR%22">Parikh AR</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hansen+A%22">Hansen A</searchLink>; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Caufield+J%22">Caufield J</searchLink>; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Newbert+G%22">Newbert G</searchLink>; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Asombang+AW%22">Asombang AW</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Casey+B%22">Casey B</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Cohen+J%22">Cohen J</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Jacobson+BC%22">Jacobson BC</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Krishnan+K%22">Krishnan K</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Uppot+R%22">Uppot R</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Weissleder+R%22">Weissleder R</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Horick+NK%22">Horick NK</searchLink>; Biostatistics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hwang+WL%22">Hwang WL</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Harisinghani+MG%22">Harisinghani MG</searchLink>; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ting+DT%22">Ting DT</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Weekes+CD%22">Weekes CD</searchLink>; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2026 Mar 02; Vol. 32 (5), pp. 869-882.
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