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Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials.

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Title: Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials.
Authors: Ferreira PCL; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Bellaver B; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Povala G; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Bauer-Negrini G; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Aguzzoli CS; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Global Brain Health Institute, University of California San Francisco, CA.; Brain Institute of Rio Grande do Sul, Porto Alegre, Brazil., Ferrari-Souza JP; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Leffa DT; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Soares C; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Lussier FZ; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Medeiros MS; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Graduate Program in Biomedical Gerontology, Pontifical Catholic University of Rio Grande do Sul, Brazil., Felix C; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Ruppert E; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Rohden F; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Borelli WV; Memory Center, Hospital Moinhos de Vento, Porto Alegre, Brazil.; Department of Morphological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Pharmacology and Therapeutics Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Karim HT; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Langhough R; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison., Christian BT; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison., Wilson R; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison., Hong CH; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea., Roh HW; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea., Patira R; Department of Neurology, School of Medicine, University of Pittsburgh, PA., Tudorascu DL; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Department of Biostatistics, School of Medicine, University of Pittsburgh, PA.; Department of Intelligent Systems, University of Pittsburgh, PA., Zimmer ER; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Memory Center, Hospital Moinhos de Vento, Porto Alegre, Brazil.; Pharmacology and Therapeutics Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; and.; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada., Betthauser TJ; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison., Karikari TK; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA., Snitz BE; Department of Neurology, School of Medicine, University of Pittsburgh, PA., Johnson SC; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison., Son SJ; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea., Pascoal TA; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Department of Neurology, School of Medicine, University of Pittsburgh, PA.
Source: Neurology [Neurology] 2026 Jan 13; Vol. 106 (1), pp. e214441. Date of Electronic Publication: 2025 Dec 09.
Publication Type: Journal Article; Observational Study; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
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  Data: Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials.
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  Data: <searchLink fieldCode="AU" term="%22Ferreira+PCL%22">Ferreira PCL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Bellaver+B%22">Bellaver B</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Povala+G%22">Povala G</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Bauer-Negrini+G%22">Bauer-Negrini G</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Aguzzoli+CS%22">Aguzzoli CS</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Global Brain Health Institute, University of California San Francisco, CA.; Brain Institute of Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferrari-Souza+JP%22">Ferrari-Souza JP</searchLink>; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Leffa+DT%22">Leffa DT</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Soares+C%22">Soares C</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Lussier+FZ%22">Lussier FZ</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Medeiros+MS%22">Medeiros MS</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Graduate Program in Biomedical Gerontology, Pontifical Catholic University of Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Felix+C%22">Felix C</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Ruppert+E%22">Ruppert E</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Rohden+F%22">Rohden F</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Borelli+WV%22">Borelli WV</searchLink>; Memory Center, Hospital Moinhos de Vento, Porto Alegre, Brazil.; Department of Morphological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Pharmacology and Therapeutics Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Karim+HT%22">Karim HT</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Langhough+R%22">Langhough R</searchLink>; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Wilson+R%22">Wilson R</searchLink>; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Hong+CH%22">Hong CH</searchLink>; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Roh+HW%22">Roh HW</searchLink>; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Patira+R%22">Patira R</searchLink>; Department of Neurology, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+DL%22">Tudorascu DL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Department of Biostatistics, School of Medicine, University of Pittsburgh, PA.; Department of Intelligent Systems, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Zimmer+ER%22">Zimmer ER</searchLink>; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Memory Center, Hospital Moinhos de Vento, Porto Alegre, Brazil.; Pharmacology and Therapeutics Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; and.; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Betthauser+TJ%22">Betthauser TJ</searchLink>; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Karikari+TK%22">Karikari TK</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Snitz+BE%22">Snitz BE</searchLink>; Department of Neurology, School of Medicine, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Son+SJ%22">Son SJ</searchLink>; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea.<br /><searchLink fieldCode="AU" term="%22Pascoal+TA%22">Pascoal TA</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, PA.; Department of Neurology, School of Medicine, University of Pittsburgh, PA.
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