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Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions.

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Title: Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions.
Authors: Tomkins J; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Edwardes LV; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Faull SV; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Peach M; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Gillespie PJ; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK., Leber V; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Schmidt A; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Bounoua H; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Sim N; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Camarillo R; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Blow JJ; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK., Barr AR; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. a.barr@lms.mrc.ac.uk.; MRC Laboratory of Medical Sciences (LMS), London, UK. a.barr@lms.mrc.ac.uk., Barnard A; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK. a.barnard@imperial.ac.uk., Speck C; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. chris.speck@imperial.ac.uk.; MRC Laboratory of Medical Sciences (LMS), London, UK. chris.speck@imperial.ac.uk.
Source: Nature communications [Nat Commun] 2025 Dec 09; Vol. 16 (1), pp. 11040. Date of Electronic Publication: 2025 Dec 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions.
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  Data: <searchLink fieldCode="AU" term="%22Tomkins+J%22">Tomkins J</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Edwardes+LV%22">Edwardes LV</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Faull+SV%22">Faull SV</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Peach+M%22">Peach M</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Gillespie+PJ%22">Gillespie PJ</searchLink>; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Leber+V%22">Leber V</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Schmidt+A%22">Schmidt A</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Bounoua+H%22">Bounoua H</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Sim+N%22">Sim N</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Camarillo+R%22">Camarillo R</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.<br /><searchLink fieldCode="AU" term="%22Blow+JJ%22">Blow JJ</searchLink>; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Barr+AR%22">Barr AR</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. a.barr@lms.mrc.ac.uk.; MRC Laboratory of Medical Sciences (LMS), London, UK. a.barr@lms.mrc.ac.uk.<br /><searchLink fieldCode="AU" term="%22Barnard+A%22">Barnard A</searchLink>; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK. a.barnard@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Speck+C%22">Speck C</searchLink>; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. chris.speck@imperial.ac.uk.; MRC Laboratory of Medical Sciences (LMS), London, UK. chris.speck@imperial.ac.uk.
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