View in EDS

Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities.

Saved in:
Bibliographic Details
Title: Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities.
Authors: Emad M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Waheed R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Mostafa Z; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Darwish SS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.; School of Life and Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation New Administrative Capital 11578 Cairo Egypt., Purgatorio R; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy., Miniero DV; Department of Medicine and Surgery, LUM University Giuseppe Degennaro Torre Rossi 70010 Casamassima Italy., De Palma A; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy., Cheng TP; Graduate Institute of Natural Products, College of Medicine, Chang Gung University Taoyuan 333 Taiwan htl@mail.cgust.edu.tw., Chen YC; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan.; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333324 Taiwan., Gabr M; Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine New York NY 10065 USA., El Kerdawy AM; School of Health and Care Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories Green Lane Lincoln UK.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street P.O. Box 11562 Cairo Egypt., Catto M; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University Taoyuan 333 Taiwan htl@mail.cgust.edu.tw.; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital Taoyuan 333 Taiwan.; School of Chinese Medicine, College of Medicine, National Yang Ming Chiao Tung University Taipei 112 Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology New Taipei City 243 Taiwan., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.
Source: RSC medicinal chemistry [RSC Med Chem] 2025 Nov 10. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41368175
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Emad+M%22">Emad M</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.<br /><searchLink fieldCode="AU" term="%22Waheed+R%22">Waheed R</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mostafa+Z%22">Mostafa Z</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.<br /><searchLink fieldCode="AU" term="%22Darwish+SS%22">Darwish SS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.; School of Life and Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation New Administrative Capital 11578 Cairo Egypt.<br /><searchLink fieldCode="AU" term="%22Purgatorio+R%22">Purgatorio R</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy.<br /><searchLink fieldCode="AU" term="%22Miniero+DV%22">Miniero DV</searchLink>; Department of Medicine and Surgery, LUM University Giuseppe Degennaro Torre Rossi 70010 Casamassima Italy.<br /><searchLink fieldCode="AU" term="%22De+Palma+A%22">De Palma A</searchLink>; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy.<br /><searchLink fieldCode="AU" term="%22Cheng+TP%22">Cheng TP</searchLink>; Graduate Institute of Natural Products, College of Medicine, Chang Gung University Taoyuan 333 Taiwan htl@mail.cgust.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan.; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333324 Taiwan.<br /><searchLink fieldCode="AU" term="%22Gabr+M%22">Gabr M</searchLink>; Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine New York NY 10065 USA.<br /><searchLink fieldCode="AU" term="%22El+Kerdawy+AM%22">El Kerdawy AM</searchLink>; School of Health and Care Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories Green Lane Lincoln UK.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street P.O. Box 11562 Cairo Egypt.<br /><searchLink fieldCode="AU" term="%22Catto+M%22">Catto M</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy.<br /><searchLink fieldCode="AU" term="%22Abadi+AH%22">Abadi AH</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.<br /><searchLink fieldCode="AU" term="%22Hwang+TL%22">Hwang TL</searchLink>; Graduate Institute of Natural Products, College of Medicine, Chang Gung University Taoyuan 333 Taiwan htl@mail.cgust.edu.tw.; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital Taoyuan 333 Taiwan.; School of Chinese Medicine, College of Medicine, National Yang Ming Chiao Tung University Taipei 112 Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology New Taipei City 243 Taiwan.<br /><searchLink fieldCode="AU" term="%22Abdel-Halim+M%22">Abdel-Halim M</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101759460%22">RSC medicinal chemistry</searchLink> [RSC Med Chem] 2025 Nov 10. <i>Date of Electronic Publication: </i>2025 Nov 10.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101759460 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-8682 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226328682%22">26328682 </searchLink><i>NLM ISO Abbreviation: </i>RSC Med Chem
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41368175
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1039/d5md00802f
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Emad M
      – PersonEntity:
          Name:
            NameFull: Waheed R
      – PersonEntity:
          Name:
            NameFull: Mostafa Z
      – PersonEntity:
          Name:
            NameFull: Darwish SS
      – PersonEntity:
          Name:
            NameFull: Purgatorio R
      – PersonEntity:
          Name:
            NameFull: Miniero DV
      – PersonEntity:
          Name:
            NameFull: De Palma A
      – PersonEntity:
          Name:
            NameFull: Cheng TP
      – PersonEntity:
          Name:
            NameFull: Chen YC
      – PersonEntity:
          Name:
            NameFull: Gabr M
      – PersonEntity:
          Name:
            NameFull: El Kerdawy AM
      – PersonEntity:
          Name:
            NameFull: Catto M
      – PersonEntity:
          Name:
            NameFull: Abadi AH
      – PersonEntity:
          Name:
            NameFull: Hwang TL
      – PersonEntity:
          Name:
            NameFull: Abdel-Halim M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 10
              M: 11
              Text: 2025 Nov 10
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2632-8682
          Titles:
            – TitleFull: RSC medicinal chemistry
              Type: main
ResultId 1