Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities.
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| Title: | Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities. |
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| Authors: | Emad M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Waheed R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Mostafa Z; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Darwish SS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg.; School of Life and Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation New Administrative Capital 11578 Cairo Egypt., Purgatorio R; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy., Miniero DV; Department of Medicine and Surgery, LUM University Giuseppe Degennaro Torre Rossi 70010 Casamassima Italy., De Palma A; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy., Cheng TP; Graduate Institute of Natural Products, College of Medicine, Chang Gung University Taoyuan 333 Taiwan htl@mail.cgust.edu.tw., Chen YC; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan.; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333324 Taiwan., Gabr M; Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine New York NY 10065 USA., El Kerdawy AM; School of Health and Care Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories Green Lane Lincoln UK.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street P.O. Box 11562 Cairo Egypt., Catto M; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro via E. Orabona 4 70125 Bari Italy., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg., Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University Taoyuan 333 Taiwan htl@mail.cgust.edu.tw.; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital Taoyuan 333 Taiwan.; School of Chinese Medicine, College of Medicine, National Yang Ming Chiao Tung University Taipei 112 Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology New Taipei City 243 Taiwan., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt Mohammad.abdel-halim@guc.edu.eg. |
| Source: | RSC medicinal chemistry [RSC Med Chem] 2025 Nov 10. Date of Electronic Publication: 2025 Nov 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem |
| Database: | MEDLINE Ultimate |
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