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Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial.

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Title: Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial.
Authors: Harrois A; Service d'Anesthésie Réanimation Chirurgicale, DMU 12 Anesthésie Réanimation Chirurgicale Médecine Péri-Opératoire et Douleur, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Saclay, Équipe DYNAMIC, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S999, Le Kremlin-Bicêtre, France., Jouffroy R; Medical Intensive Care Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France.; INSERM UMR 1018, Clinical Epidemiology Team, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Université de Paris Saclay, Villejuif, France., Ayed S; Service de Médecine Intensive-Réanimation, AP-HP, Hôpital de Bicêtre, DMU 4 CORREVE, INSERM UMR S_999, FHU SEPSIS, CARMAS, Université Paris-Saclay, Le Kremlin-Bicêtre, France., Bruel C; Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France., Savale L; AP-HP, Centre de Référence de l'Hypertension Pulmonaire, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Kremlin-Bicêtre, France., Devaux M; Internal Medicine, Saint-Germain-en-Laye Intercommunal Hospital Center, Poissy, France., Maillet M; Service de Maladies Infectieuses-Médecine Interne, Centre Hospitalier Annecy Genevois, Épagny Metz-Tessy, France., Cerf C; Polyvalent Intensive Care Unit, Hôpital Foch, Suresnes, France., Lejealle C; Réanimation Médico-Chirurgicale, Hôpital Avicenne, AP-HP, Université Sorbonne Paris Nord, Bobigny, France.; INSERM UMR_S1155, Common and Rare Kidney Diseases (CORAKID), Hôpital Tenon, Sorbonne Université, Paris, France., Moreno CG; Department of Emergency Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico., Levrat A; Anesthesiology and Critical Care Department, Annecy Hospital, Annecy, France., Gueneau R; Department of Infectious Diseases, Hôpital de Bicêtre, AP-HP, Le Kremlin-Bicêtre, France., Jouveshomme S; Service de Pneumologie, Groupe Hospitalier Paris Saint-Joseph, Paris, France., Bonnin P; Department of Infectiology, Annecy Genevois Hospital, Metz-Tessy, France., De Rudnicki S; Federation of Anesthesiology, Intensive Care Unit, Burns and Operating Theater, Percy Military Training Hospital, Clamart, France., Damoisel C; Service de Réanimation Polyvalente, Hôpital Antoine Béclère, AP-HP, Clamart, France., Gille T; INSERM U1272 Hypoxia and the Lung, Université Sorbonne Paris Nord, Bobigny, France.; Hôpitaux Universitaires de Paris Seine-Saint-Denis, sites Avicenne et Jean Verdier, Service Pneumologie et Physiologie/Explorations Fonctionnelles, AP-HP, Bobigny, France., Cordel H; Infectious Disease Department, Avicenne Hospital, Hôpitaux Universitaires Paris Seine-Saint-Denis, AP-HP, Bobigny, France.; Université Sorbonne Paris Nord, Laboratoire Éducations et Pratiques de Santé, LEPS EA 3412, Paris, France., Meslin S; Anaesthesiology and Critical Care Medicine Department, Hôpital Européen Georges Pompidou, AP-HP, Paris, France., Bocquillon V; Department of Pneumology, Annecy Genevois Hospital, Metz-Tessy, France., Noël N; AP-HP, Université Paris-Saclay, Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique, Le Kremlin-Bicêtre, France., Vieillard-Baron A; Medical Intensive Care Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France., Teboul JL; Service de Médecine Intensive-Réanimation, AP-HP, Hôpital de Bicêtre, DMU 4 CORREVE, INSERM UMR S_999, FHU SEPSIS, CARMAS, Université Paris-Saclay, Le Kremlin-Bicêtre, France., Tran M; Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France., Werner M; Service d'Anesthésie Réanimation Chirurgicale, DMU 12 Anesthésie Réanimation Chirurgicale Médecine Péri-Opératoire et Douleur, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Saclay, Équipe DYNAMIC, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S999, Le Kremlin-Bicêtre, France., Pichon J; AP-HP, Centre de Référence de l'Hypertension Pulmonaire, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Kremlin-Bicêtre, France., Janbain A; Department of Biostatistics, AP-HP, Université Paris-Diderot, Sorbonne-Paris Cité, Fernand Widal Hospital, Paris, France., Vicaut E; Department of Biostatistics, AP-HP, Université Paris-Diderot, Sorbonne-Paris Cité, Fernand Widal Hospital, Paris, France., Duranteau J; Service d'Anesthésie Réanimation Chirurgicale, DMU 12 Anesthésie Réanimation Chirurgicale Médecine Péri-Opératoire et Douleur, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Saclay, Équipe DYNAMIC, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S999, Le Kremlin-Bicêtre, France.
Corporate Authors: PROVID Study Group
Source: JAMA network open [JAMA Netw Open] 2025 Dec 01; Vol. 8 (12), pp. e2548201. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Harrois+A%22">Harrois A</searchLink>; Service d'Anesthésie Réanimation Chirurgicale, DMU 12 Anesthésie Réanimation Chirurgicale Médecine Péri-Opératoire et Douleur, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Saclay, Équipe DYNAMIC, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S999, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Jouffroy+R%22">Jouffroy R</searchLink>; Medical Intensive Care Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France.; INSERM UMR 1018, Clinical Epidemiology Team, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Université de Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ayed+S%22">Ayed S</searchLink>; Service de Médecine Intensive-Réanimation, AP-HP, Hôpital de Bicêtre, DMU 4 CORREVE, INSERM UMR S_999, FHU SEPSIS, CARMAS, Université Paris-Saclay, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Bruel+C%22">Bruel C</searchLink>; Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France.<br /><searchLink fieldCode="AU" term="%22Savale+L%22">Savale L</searchLink>; AP-HP, Centre de Référence de l'Hypertension Pulmonaire, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Devaux+M%22">Devaux M</searchLink>; Internal Medicine, Saint-Germain-en-Laye Intercommunal Hospital Center, Poissy, France.<br /><searchLink fieldCode="AU" term="%22Maillet+M%22">Maillet M</searchLink>; Service de Maladies Infectieuses-Médecine Interne, Centre Hospitalier Annecy Genevois, Épagny Metz-Tessy, France.<br /><searchLink fieldCode="AU" term="%22Cerf+C%22">Cerf C</searchLink>; Polyvalent Intensive Care Unit, Hôpital Foch, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Lejealle+C%22">Lejealle C</searchLink>; Réanimation Médico-Chirurgicale, Hôpital Avicenne, AP-HP, Université Sorbonne Paris Nord, Bobigny, France.; INSERM UMR_S1155, Common and Rare Kidney Diseases (CORAKID), Hôpital Tenon, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Moreno+CG%22">Moreno CG</searchLink>; Department of Emergency Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Levrat+A%22">Levrat A</searchLink>; Anesthesiology and Critical Care Department, Annecy Hospital, Annecy, France.<br /><searchLink fieldCode="AU" term="%22Gueneau+R%22">Gueneau R</searchLink>; Department of Infectious Diseases, Hôpital de Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Jouveshomme+S%22">Jouveshomme S</searchLink>; Service de Pneumologie, Groupe Hospitalier Paris Saint-Joseph, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bonnin+P%22">Bonnin P</searchLink>; Department of Infectiology, Annecy Genevois Hospital, Metz-Tessy, France.<br /><searchLink fieldCode="AU" term="%22De+Rudnicki+S%22">De Rudnicki S</searchLink>; Federation of Anesthesiology, Intensive Care Unit, Burns and Operating Theater, Percy Military Training Hospital, Clamart, France.<br /><searchLink fieldCode="AU" term="%22Damoisel+C%22">Damoisel C</searchLink>; Service de Réanimation Polyvalente, Hôpital Antoine Béclère, AP-HP, Clamart, France.<br /><searchLink fieldCode="AU" term="%22Gille+T%22">Gille T</searchLink>; INSERM U1272 Hypoxia and the Lung, Université Sorbonne Paris Nord, Bobigny, France.; Hôpitaux Universitaires de Paris Seine-Saint-Denis, sites Avicenne et Jean Verdier, Service Pneumologie et Physiologie/Explorations Fonctionnelles, AP-HP, Bobigny, France.<br /><searchLink fieldCode="AU" term="%22Cordel+H%22">Cordel H</searchLink>; Infectious Disease Department, Avicenne Hospital, Hôpitaux Universitaires Paris Seine-Saint-Denis, AP-HP, Bobigny, France.; Université Sorbonne Paris Nord, Laboratoire Éducations et Pratiques de Santé, LEPS EA 3412, Paris, France.<br /><searchLink fieldCode="AU" term="%22Meslin+S%22">Meslin S</searchLink>; Anaesthesiology and Critical Care Medicine Department, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bocquillon+V%22">Bocquillon V</searchLink>; Department of Pneumology, Annecy Genevois Hospital, Metz-Tessy, France.<br /><searchLink fieldCode="AU" term="%22Noël+N%22">Noël N</searchLink>; AP-HP, Université Paris-Saclay, Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Vieillard-Baron+A%22">Vieillard-Baron A</searchLink>; Medical Intensive Care Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France.<br /><searchLink fieldCode="AU" term="%22Teboul+JL%22">Teboul JL</searchLink>; Service de Médecine Intensive-Réanimation, AP-HP, Hôpital de Bicêtre, DMU 4 CORREVE, INSERM UMR S_999, FHU SEPSIS, CARMAS, Université Paris-Saclay, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Tran+M%22">Tran M</searchLink>; Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France.<br /><searchLink fieldCode="AU" term="%22Werner+M%22">Werner M</searchLink>; Service d'Anesthésie Réanimation Chirurgicale, DMU 12 Anesthésie Réanimation Chirurgicale Médecine Péri-Opératoire et Douleur, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Saclay, Équipe DYNAMIC, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S999, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Pichon+J%22">Pichon J</searchLink>; AP-HP, Centre de Référence de l'Hypertension Pulmonaire, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Thérapeutique (HPPIT), AP-HP, Hôpital Bicêtre, Hôpital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), ERN-LUNG, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Janbain+A%22">Janbain A</searchLink>; Department of Biostatistics, AP-HP, Université Paris-Diderot, Sorbonne-Paris Cité, Fernand Widal Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vicaut+E%22">Vicaut E</searchLink>; Department of Biostatistics, AP-HP, Université Paris-Diderot, Sorbonne-Paris Cité, Fernand Widal Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Duranteau+J%22">Duranteau J</searchLink>; Service d'Anesthésie Réanimation Chirurgicale, DMU 12 Anesthésie Réanimation Chirurgicale Médecine Péri-Opératoire et Douleur, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Saclay, Équipe DYNAMIC, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S999, Le Kremlin-Bicêtre, France.
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