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ZAP327 signaling domain-driven chimeric antigen receptor generates robust and long-term antitumor immunity in mouse models.

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Title: ZAP327 signaling domain-driven chimeric antigen receptor generates robust and long-term antitumor immunity in mouse models.
Authors: Liu X; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Immunova Therapeutics, LLC, Monrovia, CA 91016, USA., Zhang J; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Chu J; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA., Chen YJ; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Qian C; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA., Wang HY; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Immunova Therapeutics, LLC, Monrovia, CA 91016, USA., Wang RF; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Dec 10; Vol. 17 (828), pp. eadz0529. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ZAP327 signaling domain-driven chimeric antigen receptor generates robust and long-term antitumor immunity in mouse models.
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  Data: <searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Immunova Therapeutics, LLC, Monrovia, CA 91016, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Chu+J%22">Chu J</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Qian+C%22">Qian C</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wang+HY%22">Wang HY</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Immunova Therapeutics, LLC, Monrovia, CA 91016, USA.<br /><searchLink fieldCode="AU" term="%22Wang+RF%22">Wang RF</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Dec 10; Vol. 17 (828), pp. eadz0529. <i>Date of Electronic Publication: </i>2025 Dec 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1126/scitranslmed.adz0529
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        Text: English
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              Text: 2025 Dec 10
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