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Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.

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Title: Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.
Authors: Montellier E; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France. Electronic address: emilie.montellier@univ-grenoble-alpes.fr., Manches O; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France; EFS, R&D Department, Grenoble, France., Gaucher J; Grenoble Alpes University, HP2 Laboratory, INSERM U1300, Grenoble Alpes University Hospital, Grenoble, France., Freycon C; Department of Pediatric Hematology-Oncology, Grenoble Alpes University Hospital, Grenoble, France., Hoyos D; Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Blanchet S; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France., Verboom M; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Dutzmann CM; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Coutant S; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France., Bou J; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France., Fin B; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France., Olaso R; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France., Deleuze JF; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France., Frébourg T; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France., Greenbaum BD; Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA; The Olayan Center for Cancer Vaccines, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Levine AJ; Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA., Kratz CP; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Bougeard G; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France., Hainaut P; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
Source: EBioMedicine [EBioMedicine] 2026 Jan; Vol. 123, pp. 106065. Date of Electronic Publication: 2025 Dec 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Montellier+E%22">Montellier E</searchLink>; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France. Electronic address: emilie.montellier@univ-grenoble-alpes.fr.<br /><searchLink fieldCode="AU" term="%22Manches+O%22">Manches O</searchLink>; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France; EFS, R&D Department, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Gaucher+J%22">Gaucher J</searchLink>; Grenoble Alpes University, HP2 Laboratory, INSERM U1300, Grenoble Alpes University Hospital, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Freycon+C%22">Freycon C</searchLink>; Department of Pediatric Hematology-Oncology, Grenoble Alpes University Hospital, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Hoyos+D%22">Hoyos D</searchLink>; Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Blanchet+S%22">Blanchet S</searchLink>; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Verboom+M%22">Verboom M</searchLink>; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Dutzmann+CM%22">Dutzmann CM</searchLink>; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Coutant+S%22">Coutant S</searchLink>; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Bou+J%22">Bou J</searchLink>; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Fin+B%22">Fin B</searchLink>; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.<br /><searchLink fieldCode="AU" term="%22Olaso+R%22">Olaso R</searchLink>; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.<br /><searchLink fieldCode="AU" term="%22Deleuze+JF%22">Deleuze JF</searchLink>; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.<br /><searchLink fieldCode="AU" term="%22Frébourg+T%22">Frébourg T</searchLink>; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Greenbaum+BD%22">Greenbaum BD</searchLink>; Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA; The Olayan Center for Cancer Vaccines, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Levine+AJ%22">Levine AJ</searchLink>; Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kratz+CP%22">Kratz CP</searchLink>; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Bougeard+G%22">Bougeard G</searchLink>; Univ Rouen Normandie, Inserm U1245, Normandie Univ, CHU Rouen, Department of Genetics, F-76000, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Hainaut+P%22">Hainaut P</searchLink>; Université Grenoble Alpes, Inserm 1209, CNRS 5309, Institute for Advanced Biosciences, F38000, Grenoble, France.
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  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2026 Jan; Vol. 123, pp. 106065. <i>Date of Electronic Publication: </i>2025 Dec 09.
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