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Computational whole-body-exposome models for global precision brain health.

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Title: Computational whole-body-exposome models for global precision brain health.
Authors: Ibáñez A; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile. agustin.ibanez@gbhi.org.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland. agustin.ibanez@gbhi.org.; Department of Biophysics, Istanbul Medipol University, Istanbul, Türkiye. agustin.ibanez@gbhi.org.; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. agustin.ibanez@gbhi.org.; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Argentina. agustin.ibanez@gbhi.org., Duran-Aniotz C; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Migeot J; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland., Báez S; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Universidad de los Andes, Bogotá, Colombia., Fittipaldi S; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.; School of Psychology, Trinity College Dublin, Dublin, Ireland., Coronel-Oliveros C; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland., Eyre HA; Baker Institute for Public Policy, Rice University, Houston, TX, USA.; Global Brain Health Institute, Weill Institute of Neurosciences, University of California San Francisco (UCSF), San Francisco, USA.; Department of Psychiatry and Behavioral Sciences, UCSF, San Francisco, USA.; Euro-Mediterranean Economists Association, Barcelona, Spain., Udeh-Momoh C; Global Brain Health Institute, Weill Institute of Neurosciences, University of California San Francisco (UCSF), San Francisco, USA.; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, USA.; Brain and Mind Institute, Aga Khan University, Nairobi, Kenya., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease and UK Dementia Research Institute, UCL Queen Square Institute of Neurology, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA., Alladi S; National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India., Sandi C; Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Robertson IH; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.; Center for BrainHealth, The University of Texas at Dallas, Dallas, TX, USA., Franzen S; Department of Neurology & Alzheimer Center, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Farombi T; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.; University College Hospital, Ibadan, Nigeria., Montalvo Ortiz JL; Yale University, New Haven, USA., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA., Court F; Center for Aging Research and Healthy Longevity, Universidad Mayor, Santiago, Chile.; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.; Buck Institute for Research on Aging, Novato, USA.; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile., Valdes-Sosa P; University of Electronic Science and Technology of China, Chengdu, China.; Cuban Neuroscience Center, Havana, Cuba., Xu J; Department of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.; School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China., Yu C; Department of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.; School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China., Grinberg L; Global Brain Health Institute, Weill Institute of Neurosciences, University of California San Francisco (UCSF), San Francisco, USA.; LIM-22, Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.; UCSF School of Medicine, San Francisco, CA, USA.; Center for Population Brain Health, UCSF, San Francisco, CA, USA.; Departments of Laboratory Medicine and Pathology and Neurosciences, Mayo Clinic Florida, Jacksonville, Florida, USA., Lawlor B; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, Australia., Yaffe K; UCSF School of Medicine, San Francisco, CA, USA.; Center for Population Brain Health, UCSF, San Francisco, CA, USA., Hachinski V; Robarts Research Institute, Western University, London, Canada., Friston K; Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, London, UK., Tagliazucchi E; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales; Departamento de Física; and CONICET, Buenos Aires, Argentina., Santamaría-García H; Global Brain Health Institute, Weill Institute of Neurosciences, University of California San Francisco (UCSF), San Francisco, USA. hernando.santamaria@gbhi.org.; Pontificia Universidad Javeriana, PhD Program in Neuroscience, Bogotá, Colombia. hernando.santamaria@gbhi.org.; Hospital Universitario San Ignacio; Center for Brain and Cognition, Intellectus, Bogotá, Colombia. hernando.santamaria@gbhi.org.
Source: Nature communications [Nat Commun] 2025 Dec 11; Vol. 16 (1), pp. 11078. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ibáñez+A%22">Ibáñez A</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile. agustin.ibanez@gbhi.org.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland. agustin.ibanez@gbhi.org.; Department of Biophysics, Istanbul Medipol University, Istanbul, Türkiye. agustin.ibanez@gbhi.org.; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. agustin.ibanez@gbhi.org.; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Argentina. agustin.ibanez@gbhi.org.<br /><searchLink fieldCode="AU" term="%22Duran-Aniotz+C%22">Duran-Aniotz C</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Migeot+J%22">Migeot J</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Báez+S%22">Báez S</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Universidad de los Andes, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Fittipaldi+S%22">Fittipaldi S</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.; School of Psychology, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Coronel-Oliveros+C%22">Coronel-Oliveros C</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Eyre+HA%22">Eyre HA</searchLink>; Baker Institute for Public Policy, Rice University, Houston, TX, USA.; Global Brain Health Institute, Weill Institute of Neurosciences, University of California San Francisco (UCSF), San Francisco, USA.; Department of Psychiatry and Behavioral Sciences, UCSF, San Francisco, USA.; 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Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Court+F%22">Court F</searchLink>; Center for Aging Research and Healthy Longevity, Universidad Mayor, Santiago, Chile.; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.; Buck Institute for Research on Aging, Novato, USA.; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Valdes-Sosa+P%22">Valdes-Sosa P</searchLink>; University of Electronic Science and Technology of China, Chengdu, China.; Cuban Neuroscience Center, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.; School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Department of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.; School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Grinberg+L%22">Grinberg L</searchLink>; Global Brain Health Institute, Weill Institute of Neurosciences, University of California San Francisco (UCSF), San Francisco, USA.; LIM-22, Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.; UCSF School of Medicine, San Francisco, CA, USA.; Center for Population Brain Health, UCSF, San Francisco, CA, USA.; Departments of Laboratory Medicine and Pathology and Neurosciences, Mayo Clinic Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Lawlor+B%22">Lawlor B</searchLink>; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Sachdev+PS%22">Sachdev PS</searchLink>; 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Global Brain Health Institute, Weill Institute of Neurosciences, University of California San Francisco (UCSF), San Francisco, USA. hernando.santamaria@gbhi.org.; Pontificia Universidad Javeriana, PhD Program in Neuroscience, Bogotá, Colombia. hernando.santamaria@gbhi.org.; Hospital Universitario San Ignacio; Center for Brain and Cognition, Intellectus, Bogotá, Colombia. hernando.santamaria@gbhi.org.
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