Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly.
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| Title: | Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly. |
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| Authors: | Niehaus I; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, 30626, Germany., Wilsch-Bräuninger M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany., Mora-Bermúdez F; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany., Rost F; Technische Universität Dresden, DRESDEN-Concept Genome Center, Center for Molecular and Cellular Bioengineering (CMCB), Dresden, 01307, Germany., Bobic-Rasonja M; Croatian Institute of Brain Research and Department of Biology, School of Medicine, University of Zagreb, Zagreb, 10000, Croatia., Radosevic V; Department of Obstetrics and Gynecology, University Hospital Centre, Zagreb, 10000, Croatia., Milkovic-Perisa M; Department of Pathology and Cytology, School of Medicine, University of Zagreb and University Hospital Centre, Zagreb, 10000, Croatia., Wimberger P; Department of Gynecology and Obstetrics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany., Severino M; Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova, 16147, Italy., Haase A; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, 30625, Germany., Martin U; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, 30625, Germany., Kuenzel K; Institute of Pharmacology and Toxicology, Technische Universität Dresden, 01307, Dresden, Germany., Guan K; Institute of Pharmacology and Toxicology, Technische Universität Dresden, 01307, Dresden, Germany., Neumann K; Center for Regenerative Therapies Dresden (CRTD, Stem Cell Engineering Facility), Technische Universität Dresden, Dresden, 01307, Germany., Walker N; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany., Schröck E; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany., Jovanov-Milosevic N; Croatian Institute of Brain Research and Department of Biology, School of Medicine, University of Zagreb, Zagreb, 10000, Croatia. njovanov@hiim.hr., Huttner WB; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany. huttner@mpi-cbg.de., Di Donato N; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany. didonato.nataliya@mh-hannover.de.; Department of Human Genetics, Hannover Medical School, Hannover, 30626, Germany. didonato.nataliya@mh-hannover.de., Heide M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany. mheide@dpz.eu.; German Primate Center, Leibniz Institute for Primate Research, Göttingen, 37077, Germany. mheide@dpz.eu. |
| Source: | EMBO reports [EMBO Rep] 2026 Jan; Vol. 27 (2), pp. 387-415. Date of Electronic Publication: 2025 Dec 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.1038/s44319-025-00647-7 |
