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Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly.

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Title: Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly.
Authors: Niehaus I; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, 30626, Germany., Wilsch-Bräuninger M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany., Mora-Bermúdez F; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany., Rost F; Technische Universität Dresden, DRESDEN-Concept Genome Center, Center for Molecular and Cellular Bioengineering (CMCB), Dresden, 01307, Germany., Bobic-Rasonja M; Croatian Institute of Brain Research and Department of Biology, School of Medicine, University of Zagreb, Zagreb, 10000, Croatia., Radosevic V; Department of Obstetrics and Gynecology, University Hospital Centre, Zagreb, 10000, Croatia., Milkovic-Perisa M; Department of Pathology and Cytology, School of Medicine, University of Zagreb and University Hospital Centre, Zagreb, 10000, Croatia., Wimberger P; Department of Gynecology and Obstetrics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany., Severino M; Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova, 16147, Italy., Haase A; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, 30625, Germany., Martin U; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, 30625, Germany., Kuenzel K; Institute of Pharmacology and Toxicology, Technische Universität Dresden, 01307, Dresden, Germany., Guan K; Institute of Pharmacology and Toxicology, Technische Universität Dresden, 01307, Dresden, Germany., Neumann K; Center for Regenerative Therapies Dresden (CRTD, Stem Cell Engineering Facility), Technische Universität Dresden, Dresden, 01307, Germany., Walker N; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany., Schröck E; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany., Jovanov-Milosevic N; Croatian Institute of Brain Research and Department of Biology, School of Medicine, University of Zagreb, Zagreb, 10000, Croatia. njovanov@hiim.hr., Huttner WB; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany. huttner@mpi-cbg.de., Di Donato N; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany. didonato.nataliya@mh-hannover.de.; Department of Human Genetics, Hannover Medical School, Hannover, 30626, Germany. didonato.nataliya@mh-hannover.de., Heide M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany. mheide@dpz.eu.; German Primate Center, Leibniz Institute for Primate Research, Göttingen, 37077, Germany. mheide@dpz.eu.
Source: EMBO reports [EMBO Rep] 2026 Jan; Vol. 27 (2), pp. 387-415. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly.
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  Data: <searchLink fieldCode="AU" term="%22Niehaus+I%22">Niehaus I</searchLink>; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, 30626, Germany.<br /><searchLink fieldCode="AU" term="%22Wilsch-Bräuninger+M%22">Wilsch-Bräuninger M</searchLink>; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Mora-Bermúdez+F%22">Mora-Bermúdez F</searchLink>; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Rost+F%22">Rost F</searchLink>; Technische Universität Dresden, DRESDEN-Concept Genome Center, Center for Molecular and Cellular Bioengineering (CMCB), Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Bobic-Rasonja+M%22">Bobic-Rasonja M</searchLink>; Croatian Institute of Brain Research and Department of Biology, School of Medicine, University of Zagreb, Zagreb, 10000, Croatia.<br /><searchLink fieldCode="AU" term="%22Radosevic+V%22">Radosevic V</searchLink>; Department of Obstetrics and Gynecology, University Hospital Centre, Zagreb, 10000, Croatia.<br /><searchLink fieldCode="AU" term="%22Milkovic-Perisa+M%22">Milkovic-Perisa M</searchLink>; Department of Pathology and Cytology, School of Medicine, University of Zagreb and University Hospital Centre, Zagreb, 10000, Croatia.<br /><searchLink fieldCode="AU" term="%22Wimberger+P%22">Wimberger P</searchLink>; Department of Gynecology and Obstetrics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Severino+M%22">Severino M</searchLink>; Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genova, 16147, Italy.<br /><searchLink fieldCode="AU" term="%22Haase+A%22">Haase A</searchLink>; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, 30625, Germany.<br /><searchLink fieldCode="AU" term="%22Martin+U%22">Martin U</searchLink>; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, 30625, Germany.<br /><searchLink fieldCode="AU" term="%22Kuenzel+K%22">Kuenzel K</searchLink>; Institute of Pharmacology and Toxicology, Technische Universität Dresden, 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Guan+K%22">Guan K</searchLink>; Institute of Pharmacology and Toxicology, Technische Universität Dresden, 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Neumann+K%22">Neumann K</searchLink>; Center for Regenerative Therapies Dresden (CRTD, Stem Cell Engineering Facility), Technische Universität Dresden, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Walker+N%22">Walker N</searchLink>; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Schröck+E%22">Schröck E</searchLink>; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany.<br /><searchLink fieldCode="AU" term="%22Jovanov-Milosevic+N%22">Jovanov-Milosevic N</searchLink>; Croatian Institute of Brain Research and Department of Biology, School of Medicine, University of Zagreb, Zagreb, 10000, Croatia. njovanov@hiim.hr.<br /><searchLink fieldCode="AU" term="%22Huttner+WB%22">Huttner WB</searchLink>; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany. huttner@mpi-cbg.de.<br /><searchLink fieldCode="AU" term="%22Di+Donato+N%22">Di Donato N</searchLink>; Institute for Clinical Genetics, Technische Universität Dresden, and National Cancer Center (NCT) Dresden, Dresden, 01307, Germany. didonato.nataliya@mh-hannover.de.; Department of Human Genetics, Hannover Medical School, Hannover, 30626, Germany. didonato.nataliya@mh-hannover.de.<br /><searchLink fieldCode="AU" term="%22Heide+M%22">Heide M</searchLink>; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany. mheide@dpz.eu.; German Primate Center, Leibniz Institute for Primate Research, Göttingen, 37077, Germany. mheide@dpz.eu.
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  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 Jan; Vol. 27 (2), pp. 387-415. <i>Date of Electronic Publication: </i>2025 Dec 10.
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