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Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.

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Title: Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.
Authors: Pepper-Tunick E; Institute for Systems Biology, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA., Srinivas V; Institute for Systems Biology, Seattle, WA, USA., Mast FD; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., Li S; Seattle Children's Research Institute, Seattle, WA, USA., Russ S; Institute for Systems Biology, Seattle, WA, USA., Hanson W; Institute for Systems Biology, Seattle, WA, USA., Zamora AD; Institute for Systems Biology, Seattle, WA, USA., Wu WJ; Institute for Systems Biology, Seattle, WA, USA., Silcocks M; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia., Minh Ha DT; Pham Ngoc Thach Hospital for TB and Lung Disease, District 5, Ho Chi Minh City, Vietnam., Dunstan SJ; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia., Thuy Thuong TN; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom., Turkarslan S; Institute for Systems Biology, Seattle, WA, USA., Aitchison JD; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Arrieta-Ortiz ML; Institute for Systems Biology, Seattle, WA, USA., Baliga NS; Institute for Systems Biology, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.; Departments of Biology, Microbiology, and Civil and Environmental Engineering, University of Washington, Seattle, WA, USA.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Source: Research square [Res Sq] 2025 Dec 04. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.
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  Data: <searchLink fieldCode="AU" term="%22Pepper-Tunick+E%22">Pepper-Tunick E</searchLink>; Institute for Systems Biology, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Srinivas+V%22">Srinivas V</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mast+FD%22">Mast FD</searchLink>; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Russ+S%22">Russ S</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hanson+W%22">Hanson W</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Zamora+AD%22">Zamora AD</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+WJ%22">Wu WJ</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Silcocks+M%22">Silcocks M</searchLink>; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Minh+Ha+DT%22">Minh Ha DT</searchLink>; Pham Ngoc Thach Hospital for TB and Lung Disease, District 5, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Dunstan+SJ%22">Dunstan SJ</searchLink>; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Thuy+Thuong+TN%22">Thuy Thuong TN</searchLink>; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Turkarslan+S%22">Turkarslan S</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Aitchison+JD%22">Aitchison JD</searchLink>; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Arrieta-Ortiz+ML%22">Arrieta-Ortiz ML</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Baliga+NS%22">Baliga NS</searchLink>; Institute for Systems Biology, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.; Departments of Biology, Microbiology, and Civil and Environmental Engineering, University of Washington, Seattle, WA, USA.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
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              Text: 2025 Dec 04
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